鉴定 4H,6H-[2]苯并氧杂[4,5-c][1,2]恶唑类化合物为新型鲨烯合酶抑制剂。
Identification of 4H,6H-[2]benzoxepino[4,5-c][1,2]oxazoles as novel squalene synthase inhibitors.
机构信息
Bayer Pharma AG, Global Drug Discovery, Medicinal Chemistry Wuppertal, Wuppertal, Germany.
出版信息
Bioorg Med Chem Lett. 2011 Jun 15;21(12):3648-53. doi: 10.1016/j.bmcl.2011.04.092. Epub 2011 Apr 29.
PMID:21576018
Abstract
Novel squalene synthase inhibitors are disclosed. The design, synthesis, SAR and pharmacological profile of the compounds are discussed.
摘要
新型鲨烯合酶抑制剂被公开。化合物的设计、合成、SAR 和药理学特征被讨论。
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