RET 蛋白在乳头状肾细胞癌中的表达。
RET protein expression in papillary renal cell carcinoma.
机构信息
Department of Histopathology, St. James's Hospital, Dublin, Ireland.
出版信息
Urol Oncol. 2012 Nov-Dec;30(6):900-5. doi: 10.1016/j.urolonc.2010.08.025. Epub 2011 Mar 10.
OBJECTIVE
To examine the role of RET in renal malignancy, in particular papillary renal cell carcinoma (RCC).
MATERIALS AND METHODS
A cohort of 111 archival renal samples was used consisting of 94 renal cancers (66 papillary RCC, 18 conventional clear cell carcinoma, 10 chromophobe RCC), 4 benign oncocytomas, and 13 normal kidney tissues. RET protein expression was examined by immunohistochemistry and expression levels were correlated with clinicopathologic and patient survival data.
RESULTS
Positive RET staining was seen in 34/66 (52%) papillary RCCs, 4/10 (40%) chromophobe carcinomas, 4/4 (100%) oncocytomas, and 11/13 (85%) normal kidney samples. All 18 cases of conventional clear cell carcinoma had negative RET staining. RET expression was associated with low Fuhrman nuclear grade.
CONCLUSIONS
RET protein may be contributing in part to an adaptation of a papillary growth pattern in certain renal malignancies. Given the possible therapeutic benefit of small molecule inhibitors of RET activation, further work needs to be done to highlight the functional relevance of RET protein expression in papillary RCC.
目的
研究 RET 在肾恶性肿瘤中的作用，特别是在乳头状肾细胞癌（RCC）中的作用。
材料与方法
使用了一组 111 份存档的肾样本，包括 94 例肾癌（66 例乳头状 RCC、18 例常规透明细胞癌、10 例嫌色细胞癌）、4 例良性嗜酸细胞瘤和 13 例正常肾组织。通过免疫组织化学检测 RET 蛋白表达，并将表达水平与临床病理和患者生存数据相关联。
结果
在 66 例乳头状 RCC 中的 34 例（52%）、10 例嫌色细胞癌中的 4 例（40%）、4 例嗜酸细胞瘤中的 4 例（100%）和 13 例正常肾组织中的 11 例（85%）中观察到 RET 染色阳性。18 例常规透明细胞癌均无 RET 染色。RET 表达与低 Fuhrman 核分级相关。
结论
RET 蛋白可能在某些肾恶性肿瘤的乳头状生长模式中起一定作用。鉴于 RET 激活的小分子抑制剂可能具有治疗益处，需要进一步研究以强调 RET 蛋白表达在乳头状 RCC 中的功能相关性。
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