鸢尾素在良性和恶性肾癌中的免疫染色特征。
Immunostaining characteristics of irisin in benign and malignant renal cancers.
作者信息
Kuloğlu T, Artaş G, Yardim M, Sahin I, Aydin Y, Beyoğlu N, Özercan I H, Yalcin M H, Ugur K, Aydin S
机构信息
Department of Histology and Embryology, School of Medicine, Firat University , Elazig.
Department of Pathology, School of Medicine, Firat University , Elazig , Turkey.
出版信息
Biotech Histochem. 2019 Aug;94(6):435-441. doi: 10.1080/10520295.2019.1586998. Epub 2019 Mar 21.
We investigated the expression of irisin in renal cancers using immunocytochemistry. Irisin has been reported to exhibit anticancer properties. The study groups consisted of 22 cases each of control renal tissue, oncocytoma, chromophobe renal cell carcinoma (RCC), clear cell RCC (Fuhrman nuclear grades 1, 2, 3 and 4) and papillary RCC. We evaluated 10 slides for each of 176 cases. Slides were immunostained for irisin and histoscores were calculated for the prevalence and strength of immunostaining. Fuhrman nuclear grade 1, 2, 3 clear cell RCC and papillary RCC exhibited no irisin immunoreactivity. Irisin immunoreactivity was observed in some Fuhrman nuclear grade 4 RCCs. We found a significant decrease in irisin staining in chromophobe RCC compared to the control. Immunoreactivity in the oncocytoma tissue was comparable to the control group. Irisin immunoreactivity in chromophobe RCC decreased and no immunoreactivity was observed in Fuhrman nuclear grade 1, 2, 3 clear cell RCC and papillary RCC. Immunistochemical screening of irisin in renal oncocytomas and renal cancers may be useful for differential diagnosis.
我们采用免疫细胞化学方法研究了鸢尾素在肾癌中的表达情况。据报道，鸢尾素具有抗癌特性。研究组包括22例对照肾组织、嗜酸细胞瘤、嫌色肾细胞癌（RCC）、透明细胞RCC（福尔曼核分级1、2、3和4级）以及乳头状RCC。我们对176例中的每例评估了10张玻片。玻片进行鸢尾素免疫染色，并计算免疫染色的患病率和强度的组织学评分。福尔曼核分级1、2、3级的透明细胞RCC和乳头状RCC未表现出鸢尾素免疫反应性。在一些福尔曼核分级4级的RCC中观察到鸢尾素免疫反应性。我们发现，与对照组相比，嫌色RCC中鸢尾素染色显著减少。嗜酸细胞瘤组织中的免疫反应性与对照组相当。嫌色RCC中的鸢尾素免疫反应性降低，而福尔曼核分级1、2、3级的透明细胞RCC和乳头状RCC中未观察到免疫反应性。对肾嗜酸细胞瘤和肾癌中的鸢尾素进行免疫组织化学筛查可能有助于鉴别诊断。
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