Department of Molecular Biology & Biochemistry, Rutgers, Piscataway, NJ 08854, USA.
Arch Biochem Biophys. 2011 Jun 15;510(2):76-82. doi: 10.1016/j.abb.2011.03.002. Epub 2011 Mar 21.
At mitosis, cells undergo drastic alterations in morphology and cytoskeletal organization including cell rounding during prophase, mitotic spindle assembly during prometaphase and metaphase, chromatid segregation in anaphase, and cytokinesis during telophase. It is well established that myosin II is a motor responsible for cytokinesis. Recent reports have indicated that myosin II is also involved in spindle assembly and karyokinesis. In this review, we summarize current understanding of the functions of myosin II in mitosis and cytokinesis of higher eukaryotes, and discuss the roles of possible upstream molecules that control myosin II in these mitotic events.
在有丝分裂过程中，细胞的形态和细胞骨架组织发生剧烈变化，包括前期的细胞变圆、前中期的有丝分裂纺锤体组装、中期的染色单体分离以及末期的胞质分裂。肌球蛋白 II 是一种负责胞质分裂的马达，这一点已得到充分证实。最近的报告表明，肌球蛋白 II 也参与纺锤体组装和核分裂。在这篇综述中，我们总结了肌球蛋白 II 在高等真核生物有丝分裂和胞质分裂中的功能的现有认识，并讨论了控制这些有丝分裂事件中肌球蛋白 II 的可能上游分子的作用。
