Instituto Multidisciplinar em Saúde, Universidade Federal da Bahia, Vitória da Conquista 45029094, Brazil.
Campus Toledo, Universidade Federal do Paraná, Toledo 85919899, Brazil.
World J Gastroenterol. 2023 Aug 28;29(32):4851-4859. doi: 10.3748/wjg.v29.i32.4851.
Marginal zone lymphomas rank as the third most prevalent form of non-Hodgkin B-cell lymphoma, trailing behind diffuse large B-cell lymphoma and follicular lymphoma. Gastric mucosa-associated lymphoid tissue lymphoma (GML) is a low-grade B-cell neoplasia frequently correlated with ()-induced chronic gastritis. On the other hand, a specific subset of individuals diagnosed with GML does not exhibit infection. In contrast to its -positive counterpart, it was previously believed that -negative GML was less likely to respond to antimicrobial therapy. Despite this, surprisingly, in-creasing evidence supports that a considerable proportion of patients with -negative GML show complete histopathological remission after bacterial eradication therapy. Nonetheless, the precise mechanisms underlying this treatment responsiveness are not yet fully comprehended. In recent years, there has been growing interest in investigating the role of non- gastric helicobacters (NHPHs) in the pathogenesis of -negative GML. However, additional research is required to establish the causal relationship between NHPHs and GML. In this minireview, we examined the current understanding and proposed prospects on the involvement of NHPHs in -negative GML, as well as their potential response to bacterial eradication therapy.
边缘带淋巴瘤是继弥漫性大 B 细胞淋巴瘤和滤泡性淋巴瘤之后的第三大常见非霍奇金 B 细胞淋巴瘤，胃黏膜相关淋巴组织淋巴瘤（GML）是一种低度 B 细胞肿瘤，常与幽门螺杆菌（）诱导的慢性胃炎相关。另一方面，诊断为 GML 的特定亚组人群并不表现出感染。与阳性病例相比，先前认为阴性 GML 不太可能对抗菌治疗产生反应。尽管如此，令人惊讶的是，越来越多的证据支持相当一部分阴性 GML 患者在细菌根除治疗后可完全达到组织病理学缓解。然而，对于这种治疗反应的具体机制尚不完全清楚。近年来，人们越来越关注研究非胃螺旋杆菌（NHPHs）在阴性 GML 发病机制中的作用。然而，还需要进一步的研究来确定 NHPHs 与 GML 之间的因果关系。在这篇综述中，我们检查了目前对 NHPHs 参与阴性 GML 的认识和提出的前景，以及它们对细菌根除治疗的潜在反应。
