Qiu W Q, de Bruin D, Brownstein B H, Pearse R, Ravetch J V
Division of Molecular Biology, Sloan-Kettering Institute, New York, NY 10021.
Science. 1990 May 11;248(4956):732-5. doi: 10.1126/science.2139735.
Receptors for immunoglobulin G immune complexes (Fc gamma RII and Fc gamma RIII) are expressed on most hematopoietic cells and show much structural and functional diversity. In order to determine the genetic basis for this diversity, a family of genes encoding the human and mouse receptors was isolated and characterized. Humans have five distinct genes for low-affinity Fc gamma Rs, in contrast to two in the mouse. With the use of yeast artificial chromosomes, the genes encoding the human receptors were oriented and linked, which established the structure of this complex locus. Comparison of the human and mouse genes generated a model for the evolutionary amplification of this locus.
免疫球蛋白G免疫复合物的受体（FcγRII和FcγRIII）在大多数造血细胞上表达，并表现出很大的结构和功能多样性。为了确定这种多样性的遗传基础，分离并鉴定了一个编码人和小鼠受体的基因家族。人类有五个不同的低亲和力FcγR基因，而小鼠有两个。利用酵母人工染色体，确定了编码人类受体的基因的方向并将它们连接起来，从而建立了这个复合基因座的结构。对人和小鼠基因的比较产生了该基因座进化扩增的模型。
