Hassan H, O'Hare M D, Felmingham D
Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur.
Singapore Med J. 1990 Feb;31(1):56-8.
The in vitro activity of teicoplanin and A16686, two new glycopeptide antibiotics was determined against 196 isolates of anaerobic bacteria. The activity of teicoplanin and A16686, in comparison with that of vancomycin, clindamycin, erythromycin and fusidic acid was 2 to 16 times higher against the gram positive anaerobes, namely, Propionibacterium acnes, Clostridium perfringens, Clostridium difficile, Clostridium species, Peptococcus species and Peptostreptococcus species. However, Bacteroides fragilis was resistant to teicoplanin and A16686 while Bacteroides melaninogenicus and Bacteroides bivius were found to be sensitive.
测定了两种新型糖肽类抗生素替考拉宁和A16686对196株厌氧菌的体外活性。与万古霉素、克林霉素、红霉素和夫西地酸相比，替考拉宁和A16686对革兰氏阳性厌氧菌，即痤疮丙酸杆菌、产气荚膜梭菌、艰难梭菌、梭菌属、消化球菌属和消化链球菌属的活性高2至16倍。然而，脆弱拟杆菌对替考拉宁和A16686耐药，而产黑素拟杆菌和二路拟杆菌敏感。
