Registre général des cancers de Lille et de sa région, F-59120 Loos, France.
Oral Oncol. 2011 Apr;47(4):302-7. doi: 10.1016/j.oraloncology.2011.02.013.
Over the 1998-2002 period, some French Départements have been shown to have the world's highest incidence of upper aerodigestive tract (UADT) cancers in men. The objectives were to describe the changes in UADT cancer incidence in France over the 1980-2005 period, present projections for 2010, and describe the anatomical and histological characteristics of these tumours. The trend of cancer-incidence over 1980-2005 and projection up to 2010 were obtained using age-period-cohort models (data from eleven cancer registries) and incidence/mortality ratios in the area covered by these registries. The description of UADT cancers by anatomical and histological characteristics concerned data collected between 1980 and 2004 in eleven cancer registries. In men, cancer incidence decreased in all cancer sites and the world-standardized incidence rates decreased by 42.9% for lip-oral cavity-pharynx (LOCP) cancers and 50.4% for larynx cancer. In women, the world-standardized incidence rates increased by 48.6% for LOCP cancers and 66.7% for larynx cancer. Incidence increased the most for oropharynx, palate, and hypopharynx cancers. Incidence analysis by one-year cohorts revealed a progressive shift of the incidence peak towards younger and younger generations, with no change as yet in the mean age at diagnosis. In France, the incidence of these cancers is still higher than in other European and North American countries. This urges actions towards reducing the major risk factors for those cancers, namely alcohol and tobacco consumption, especially among young people, and reducing exposure to risk factors due to social inequalities.
在 1998 年至 2002 年期间，一些法国省被发现其男性上呼吸道（UADT）癌症的发病率居世界之首。目的是描述法国在 1980 年至 2005 年期间 UADT 癌症发病率的变化，展示 2010 年的预测，并描述这些肿瘤的解剖和组织学特征。使用年龄-时期-队列模型（来自 11 个癌症登记处的数据）和这些登记处覆盖区域的发病率/死亡率比，获得了 1980 年至 2005 年的癌症发病率趋势和 2010 年的预测。通过 11 个癌症登记处收集的 1980 年至 2004 年的数据，对 UADT 癌症进行了解剖和组织学特征描述。在男性中，所有癌症部位的癌症发病率均下降，唇-口腔-咽（LOCP）癌症的世界标准化发病率下降了 42.9%，喉癌下降了 50.4%。在女性中，LOCP 癌症的世界标准化发病率上升了 48.6%，喉癌上升了 66.7%。口咽、腭和下咽癌症的发病率增长最为显著。通过一年一年的队列分析，发现发病率峰值逐渐向年轻一代转移，而诊断时的平均年龄尚未发生变化。在法国，这些癌症的发病率仍然高于其他欧洲和北美国家。因此，有必要采取行动，减少这些癌症的主要危险因素，即酒精和烟草的消费，尤其是在年轻人中，并减少因社会不平等而导致的风险因素暴露。
