阿昔洛韦与碘苷治疗树枝状角膜溃疡的随机双盲试验。
Randomised double-blind trial of acyclovir and idoxuridine in dendritic corneal ulceration.
作者信息
Collum L M, Benedict-Smith A, Hillary I B
出版信息
Br J Ophthalmol. 1980 Oct;64(10):766-9. doi: 10.1136/bjo.64.10.766.
Abstract
The results of a randomised double-blind clinical trial of 3% acyclovir and 0.5% idoxuridine (IDU) ophthalmic ointments in 60 patients with corneal dendritic ulceration are presented. Ulcers in all 30 patients treated with acyclovir healed compared with 22 (76%) of 29 patients treated with IDU (P < 0.01). Patients treated with acyclovir healed more rapidly (average 4.4 days) than those who received IDU (average 9.2 days) (P < 0.01). No serious side effects were observed, though transient stinging was recorded in 8 patients receiving acyclovir and in 2 patients receiving IDU. Other side effects in the IDU treated group were watering in 2 patients and superficial punctate erosions in 6 patients.
摘要
本文介绍了一项针对60例角膜树枝状溃疡患者的随机双盲临床试验结果，该试验比较了3%阿昔洛韦眼膏和0.5%碘苷（IDU）眼膏的疗效。接受阿昔洛韦治疗的30例患者的溃疡均愈合，而接受IDU治疗的29例患者中有22例（76%）愈合（P<0.01）。接受阿昔洛韦治疗的患者愈合速度更快（平均4.4天），快于接受IDU治疗的患者（平均9.2天）（P<0.01）。未观察到严重副作用，不过8例接受阿昔洛韦治疗的患者和2例接受IDU治疗的患者记录有短暂刺痛。IDU治疗组的其他副作用包括2例患者流泪，6例患者出现浅层点状糜烂。
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本文引用的文献
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Use of 5-iodo-2'-deoxyuridine (IDU) in treatment of herpes simplex keratitis.5-碘-2'-脱氧尿苷（IDU）在单纯疱疹性角膜炎治疗中的应用。
Arch Ophthalmol. 1962 Aug;68:235-9. doi: 10.1001/archopht.1962.00960030239015.
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TREATMENT OF HUMAN HERPES SIMPLEX KERATITIS WITH IDOXURIDINE.用碘苷治疗人类单纯疱疹性角膜炎。
Arch Ophthalmol. 1965 May;73:623-34. doi: 10.1001/archopht.1965.00970030625006.
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CONTROLLED STUDIES OF IDU IN THE TREATMENT OF HERPETIC KERATITIS.关于注射用碘苷治疗疱疹性角膜炎的对照研究。
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AN EVALUATION OF DOUBLE-BLIND IDU THERAPY IN 100 CASES OF HERPETIC KERATITIS.100例疱疹性角膜炎双盲眼内注射疗法评估
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A DOUBLE-BLIND STUDY OF IDU IN HUMAN HERPES SIMPLEX KERATITIS.阿昔洛韦治疗人类单纯疱疹病毒性角膜炎的双盲研究。 （注：这里的IDU如果是指碘苷的话，原文标题不太准确，正常应该是IDOXURIDINE即碘苷，不过按给定内容翻译如此。如果IDU另有他意，请根据准确含义调整译文）
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Clinical evaluation of trifluorothymidine in the treatment of herpes simplex corneal ulcers.三氟胸苷治疗单纯疱疹性角膜溃疡的临床评估
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A double blind clinical study of adenine arabinoside therapy of viral keratoconjunctivitis.阿糖腺苷治疗病毒性角结膜炎的双盲临床研究。
Am J Ophthalmol. 1972 Jul;74(1):81-8. doi: 10.1016/0002-9394(72)91130-0.
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Treatment of herpetic keratitis.疱疹性角膜炎的治疗。
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Double--blind clinical trial of adenine arabinoside and idoxuridine in herpetic corneal ulcers.阿糖腺苷与碘苷治疗疱疹性角膜溃疡的双盲临床试验
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