• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

SIRT3 通过调节 ROS 和 HIF 来控制癌症代谢重编程。

SIRT3 controls cancer metabolic reprogramming by regulating ROS and HIF.

机构信息

Department of Pediatrics, Northwestern University Feinberg School of Medicine, 310 E. Superior St. Searle Bldg. 4-685, Chicago, IL 60611, USA.

出版信息

Cancer Cell. 2011 Mar 8;19(3):299-300. doi: 10.1016/j.ccr.2011.03.001.

DOI:10.1016/j.ccr.2011.03.001
PMID:21397853
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3087169/
Abstract

In this issue of Cancer Cell, Finley and coworkers report that the genetic loss of the deacetylase SIRT3 leads to metabolic reprogramming toward glycolysis. This shift is mediated by an increase in cellular reactive oxygen species (ROS) generation that amplifies HIF-α stabilization and HIF-dependent gene expression, thereby driving the tumor phenotype.

摘要

在本期《癌细胞》杂志中，Finley 及其同事报告称，去乙酰化酶 SIRT3 的遗传缺失会导致代谢向糖酵解重新编程。这种转变是由细胞内活性氧（ROS）生成的增加介导的，它放大了 HIF-α 的稳定和 HIF 依赖性基因表达，从而驱动肿瘤表型。

相似文献

1
SIRT3 controls cancer metabolic reprogramming by regulating ROS and HIF.SIRT3 通过调节 ROS 和 HIF 来控制癌症代谢重编程。
Cancer Cell. 2011 Mar 8;19(3):299-300. doi: 10.1016/j.ccr.2011.03.001.
2
SIRT3 opposes reprogramming of cancer cell metabolism through HIF1α destabilization.SIRT3 通过使 HIF1α 不稳定来抵制癌细胞代谢的重编程。
Cancer Cell. 2011 Mar 8;19(3):416-28. doi: 10.1016/j.ccr.2011.02.014.
3
SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS production.SirT3 通过抑制线粒体 ROS 产生来抑制缺氧诱导因子 1α 和肿瘤生长。
Oncogene. 2011 Jun 30;30(26):2986-96. doi: 10.1038/onc.2011.37. Epub 2011 Feb 28.
4
SIRT3 elicited an anti-Warburg effect through HIF1α/PDK1/PDHA1 to inhibit cholangiocarcinoma tumorigenesis.SIRT3 通过 HIF1α/PDK1/PDHA1 诱导抗 Warburg 效应，抑制胆管癌发生。
Cancer Med. 2019 May;8(5):2380-2391. doi: 10.1002/cam4.2089. Epub 2019 Apr 16.
5
SIRT3 is a mitochondrial tumor suppressor: a scientific tale that connects aberrant cellular ROS, the Warburg effect, and carcinogenesis.SIRT3 是一种线粒体肿瘤抑制因子：一个将异常细胞 ROS、沃伯格效应和致癌作用联系起来的科学故事。
Cancer Res. 2012 May 15;72(10):2468-72. doi: 10.1158/0008-5472.CAN-11-3633.
6
SIRT3 Regulates the ROS-FPR1/HIF-1α Axis under Hypoxic Conditions to Influence Lung Cancer Progression.SIRT3 通过调控低氧条件下 ROS-FPR1/HIF-1α 轴影响肺癌进展。
Cell Biochem Biophys. 2023 Dec;81(4):813-821. doi: 10.1007/s12013-023-01180-x. Epub 2023 Sep 25.
7
Sirtuin 3 deficiency does not augment hypoxia-induced pulmonary hypertension.Sirtuin 3 缺乏不会增强低氧诱导的肺动脉高压。
Am J Respir Cell Mol Biol. 2013 Dec;49(6):885-91. doi: 10.1165/rcmb.2013-0191OC.
8
Reciprocal metabolic reprogramming through lactate shuttle coordinately influences tumor-stroma interplay.通过乳酸穿梭实现的代谢互惠重编程协调影响肿瘤-基质相互作用。
Cancer Res. 2012 Oct 1;72(19):5130-40. doi: 10.1158/0008-5472.CAN-12-1949. Epub 2012 Jul 31.
9
Endothelial Sirtuin 3 Dictates Glucose Transport to Cardiomyocyte and Sensitizes Pressure Overload-Induced Heart Failure.内皮细胞 Sirtuin 3 决定葡萄糖向心肌细胞的转运，并使压力超负荷诱导的心力衰竭敏感化。
J Am Heart Assoc. 2020 Jun 2;9(11):e015895. doi: 10.1161/JAHA.120.015895. Epub 2020 May 29.
10
Lactate preconditioning promotes a HIF-1α-mediated metabolic shift from OXPHOS to glycolysis in normal human diploid fibroblasts.乳酸预处理可促进正常人类二倍体成纤维细胞中由 HIF-1α 介导的代谢从 OXPHOS 向糖酵解的转变。
Sci Rep. 2020 May 20;10(1):8388. doi: 10.1038/s41598-020-65193-9.

引用本文的文献

1
Exercise performance in well-trained male mice is promoted by intermittent hyperoxia via improving metabolic properties and capillary profiles.间歇性高氧通过改善代谢特性和毛细血管形态，促进训练有素的雄性小鼠的运动表现。
Physiol Rep. 2025 Apr;13(8):e70341. doi: 10.14814/phy2.70341.
2
Identification of small molecular inhibitors of SIRT3 by computational and biochemical approaches a potential target of breast cancer.通过计算和生化方法鉴定 SIRT3 的小分子抑制剂——乳腺癌的潜在靶点
Sci Rep. 2024 May 30;14(1):12475. doi: 10.1038/s41598-024-63177-7.
3
Bioinformatics Identification of Regulatory Genes and Mechanism Related to Hypoxia-Induced PD-L1 Inhibitor Resistance in Hepatocellular Carcinoma.生物信息学鉴定与肝细胞癌缺氧诱导的 PD-L1 抑制剂耐药相关的调控基因及机制
Int J Mol Sci. 2023 May 13;24(10):8720. doi: 10.3390/ijms24108720.
4
SIRT3-dependent delactylation of cyclin E2 prevents hepatocellular carcinoma growth.SIRT3 依赖性去酰化 cyclin E2 可预防肝细胞癌生长。
EMBO Rep. 2023 May 4;24(5):e56052. doi: 10.15252/embr.202256052. Epub 2023 Mar 10.
5
Hypoxia-induced ROS aggravate tumor progression through HIF-1α-SERPINE1 signaling in glioblastoma.缺氧诱导的活性氧通过 HIF-1α-SERPINE1 信号加重胶质母细胞瘤的肿瘤进展。
J Zhejiang Univ Sci B. 2023 Jan 15;24(1):32-49. doi: 10.1631/jzus.B2200269.
6
Apelin-13 Attenuates Lipopolysaccharide-Induced Inflammatory Responses and Acute Lung Injury by Regulating PFKFB3-Driven Glycolysis Induced by NOX4-Dependent ROS.Apelin-13通过调节由NOX4依赖性活性氧诱导的PFKFB3驱动的糖酵解来减轻脂多糖诱导的炎症反应和急性肺损伤。
J Inflamm Res. 2022 Mar 30;15:2121-2139. doi: 10.2147/JIR.S348850. eCollection 2022.
7
Bioinformatic Analysis of the Effect of the Family on Differentiated Thyroid Carcinoma.家族因素对分化型甲状腺癌影响的生物信息学分析。
Biomed Res Int. 2022 Jan 30;2022:5794118. doi: 10.1155/2022/5794118. eCollection 2022.
8
HIF2α promotes tumour growth in clear cell renal cell carcinoma by increasing the expression of NUDT1 to reduce oxidative stress.缺氧诱导因子 2α 通过增加 NUDT1 的表达来减少氧化应激，从而促进肾透明细胞癌的肿瘤生长。
Clin Transl Med. 2021 Nov;11(11):e592. doi: 10.1002/ctm2.592.
9
Stress Responses as Master Keys to Epigenomic Changes in Transcriptome and Metabolome for Cancer Etiology and Therapeutics.应激反应作为转录组和代谢组表观基因组变化的主钥匙，用于癌症病因学和治疗学。
Mol Cell Biol. 2022 Jan 20;42(1):e0048321. doi: 10.1128/MCB.00483-21. Epub 2021 Nov 8.
10
Systemic application of honokiol prevents cisplatin ototoxicity without compromising its antitumor effect.厚朴酚的全身应用可预防顺铂耳毒性，而不影响其抗肿瘤效果。
Am J Cancer Res. 2020 Dec 1;10(12):4416-4434. eCollection 2020.

本文引用的文献

1
SIRT3 opposes reprogramming of cancer cell metabolism through HIF1α destabilization.SIRT3 通过使 HIF1α 不稳定来抵制癌细胞代谢的重编程。
Cancer Cell. 2011 Mar 8;19(3):416-28. doi: 10.1016/j.ccr.2011.02.014.
2
SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress.SIRT3 是一种定位于线粒体的肿瘤抑制因子，在应激过程中维持线粒体的完整性和代谢。
Cancer Cell. 2010 Jan 19;17(1):41-52. doi: 10.1016/j.ccr.2009.11.023.
3
A tumor suppressor SIRTainty.肿瘤抑制因子 SIRTainty。
Cancer Cell. 2010 Jan 19;17(1):5-6. doi: 10.1016/j.ccr.2009.12.032.
4
Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics.定义缺氧诱导因子 1 在癌症生物学和治疗学中的作用。
Oncogene. 2010 Feb 4;29(5):625-34. doi: 10.1038/onc.2009.441. Epub 2009 Nov 30.
5
HIF-1: upstream and downstream of cancer metabolism.缺氧诱导因子 1：癌症代谢的上下游。
Curr Opin Genet Dev. 2010 Feb;20(1):51-6. doi: 10.1016/j.gde.2009.10.009. Epub 2009 Nov 26.
6
Understanding the Warburg effect: the metabolic requirements of cell proliferation.理解瓦伯格效应：细胞增殖的代谢需求。
Science. 2009 May 22;324(5930):1029-33. doi: 10.1126/science.1160809.
7
SIRT3 interacts with the daf-16 homolog FOXO3a in the mitochondria, as well as increases FOXO3a dependent gene expression.SIRT3在线粒体中与daf-16同源物FOXO3a相互作用，并增加FOXO3a依赖性基因表达。
Int J Biol Sci. 2008 Sep 5;4(5):291-9. doi: 10.7150/ijbs.4.291.
8
On respiratory impairment in cancer cells.论癌细胞中的呼吸损伤。
Science. 1956 Aug 10;124(3215):269-70.
9
Mitochondrial reactive oxygen species trigger hypoxia-induced transcription.线粒体活性氧引发缺氧诱导的转录。
Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):11715-20. doi: 10.1073/pnas.95.20.11715.