Department of Endocrinology, Far EasternMemorial Hospital, Taipei County, Taiwan.
Diabetes Care. 2011 May;34(5):1177-9. doi: 10.2337/dc10-2006. Epub 2011 Mar 11.
We prospectively assessed the age- and sex-specific incidence and relative risk of malignant neoplasm of the pancreas in Taiwan's diabetic population.
A total of 615,532 diabetic patients and 614,871 age- and sex-matched control subjects were linked to inpatient claims (2000-2006) to identify the admissions for malignant neoplasm of the pancreas (ICD-9: 157). The Cox proportional hazards regression model was used to estimate the age- and sex-specific relative risk of pancreatic neoplasm.
Compared with the control group, the diabetic patients had a significantly increased risk of pancreatic cancer (hazard ratio [HR] 1.54 [95% CI 1.39-1.71]). The higher and significant age-specific HRs were observed in diabetic men (1.91) and women (1.80) aged 45-65 years.
Middle-aged diabetic men and women were associated with the most increased risk of malignant neoplasm of the pancreas.
我们前瞻性评估了台湾地区糖尿病患者中胰腺恶性肿瘤的年龄和性别特异性发病率和相对风险。
将 615532 例糖尿病患者和 614871 名年龄和性别匹配的对照组患者进行链接，以确定（2000-2006 年）因胰腺恶性肿瘤（ICD-9：157）住院的病例。使用 Cox 比例风险回归模型来估计胰腺肿瘤的年龄和性别特异性相对风险。
与对照组相比，糖尿病患者患胰腺癌的风险显著增加（风险比 [HR] 1.54 [95% CI 1.39-1.71]）。在年龄在 45-65 岁的糖尿病男性（1.91）和女性（1.80）中，观察到更高且显著的年龄特异性 HR。
中年糖尿病男性和女性患胰腺恶性肿瘤的风险最高。
