Hoyos Mauricio, Moore Lee, Williams P Stephen, Zborowski Maciej
Laboratoire de Physique et Mécanique des Milieux Hétérogènes, ESPCI, Paris, 75005, France.
J Magn Magn Mater. 2011 May 1;323(10):1384-1388. doi: 10.1016/j.jmmm.2010.11.051.
The Quadrupole Magnetic Sorter (QMS), employing an annular flow channel concentric with the aperture of a quadrupole magnet, is well established for cell and particle separations. Here we propose a magnetic particle separator comprising a linear array of cylindrical magnets, analogous to the array proposed by Klaus Halbach, mated to a substantially improved form of parallel-plate SPLITT channel, known as the step-SPLITT channel. While the magnetic force and throughput are generally lower than for the QMS, the new separator has advantages in ease of fabrication and the ability to vary the magnetic force to suit the separands. Preliminary experiments yield results consistent with prediction and show promise regarding future separations of cells of biomedical interest.
四极磁分选器（QMS）采用与四极磁体孔径同心的环形流动通道，在细胞和颗粒分离方面已得到广泛应用。在此，我们提出一种磁颗粒分离器，它由圆柱形磁体的线性阵列组成，类似于克劳斯·哈尔巴赫提出的阵列，并与一种经过大幅改进的平行板SPLITT通道（即阶梯式SPLITT通道）相结合。虽然磁力和通量通常低于QMS，但这种新型分离器在制造简便性以及能够改变磁力以适应被分离物方面具有优势。初步实验结果与预测一致，并显示出在未来分离具有生物医学意义的细胞方面的潜力。
