Department of Orthopaedics, Massachusetts General Hospital, Boston, Massachusetts, USA.
J Surg Oncol. 2011 Apr;103(5):386-9. doi: 10.1002/jso.21835. Epub 2010 Dec 29.
The objective of this study is to present two series of cases of pigmented villonodular disease of joints (PVNS) treated at different periods. The 215 cases from our hospital are current (1972-2009) and those 62 from the Jaffe collection from 1920 to 1968.
By use of our computerized tumor data system we were able to define age, gender, site, treatment, complications, and outcome. Examination of the material from the Jaffe collection included all of the above primary data but none on treatment and outcome.
The data for the two systems studied were remarkably similar. The average ages were in mid years and the disorder was more frequent in females. The largest numbers of cases for both series were in the knee and foot and less commonly in hip, shoulder, and hand. The treatments were mostly surgical excision with the exception of the hip which required total hip replacement. The results show only a small number of recurrences, no metastatic disease and no deaths.
Pigmented villonodular disease of joints is a rare entity, mostly occurring in the knee and foot. The principal treatment is surgical excision which is most often successful in these sites but leads to problems at other locations, especially the hip.
本研究旨在介绍两批不同时期治疗的关节色素绒毛结节性滑膜炎（PVNS）病例。我们医院的 215 例为当前病例（1972-2009 年），而 Jaffe 收藏的 62 例则来自 1920 年至 1968 年。
通过使用我们的计算机肿瘤数据系统，我们能够定义年龄、性别、部位、治疗、并发症和结果。对 Jaffe 收藏的材料进行检查包括所有上述原始数据，但没有关于治疗和结果的数据。
两个系统研究的数据非常相似。平均年龄在中年，女性发病率较高。两个系列中膝关节和足部的病例最多，髋、肩和手部较少。治疗方法主要是手术切除，除了需要全髋关节置换的髋关节。结果显示只有少数复发，无转移疾病，无死亡。
关节色素绒毛结节性滑膜炎是一种罕见的疾病，主要发生在膝关节和足部。主要治疗方法是手术切除，在这些部位通常是成功的，但会在其他部位引起问题，特别是髋关节。
