Kimura Hiroshi
Department of Virology, Nagoya University Graduate School of Medicine.
Nihon Rinsho. 2011 Mar;69(3):437-41.
Herpes simplex encephalitis, which is caused by herpes simplex virus type 1 and type 2, is a severe central nervous system infection. This disease starts with fever, convulsion, and impaired consciousness, and often accompanies with temporal robe symptoms such as hallucination, cognitive disturbance. In spite of the establishments of early diagnosis by polymerase chain reaction (PCR) and effective antiviral therapies, the prognosis of herpes simplex encephalitis is still poor and often accompanies neurological deficits. New treatment strategy including combination therapy should be developed to ameliorate the prognosis of the disease.
单纯疱疹性脑炎由1型和2型单纯疱疹病毒引起，是一种严重的中枢神经系统感染。该病始于发热、惊厥和意识障碍，常伴有颞叶症状，如幻觉、认知障碍。尽管通过聚合酶链反应（PCR）实现了早期诊断并采用了有效的抗病毒治疗，但单纯疱疹性脑炎的预后仍然很差，且常伴有神经功能缺损。应制定包括联合治疗在内的新治疗策略以改善该病的预后。
