从桑属植物中分离得到的异戊烯基类黄酮和促进脂肪生成的成分。

Isoprenylated flavonoids and adipogenesis-promoting constituents from Morus nigra.

机构信息

Department of Pharmacognosy, School of Pharmacy, Fudan University, 826 Zhang Heng Road, Shanghai 201203, People's Republic of China.

出版信息

J Nat Prod. 2011 Apr 25;74(4):816-24. doi: 10.1021/np100907d. Epub 2011 Mar 14.

DOI:10.1021/np100907d

PMID:21401118

Abstract

Ten new isoprenylated flavonoids, nigrasins A-J (1-10), and three known compounds were isolated from the twigs of Morus nigra. Compounds 8 and 9 promoted adipogenesis, characterized by increased lipid droplet and triglyceride content in 3T3L1 cells, and induced up-regulation of the expression of adipocyte-specific genes, aP2 and GLUT4.

摘要

从桑枝中分离得到了 10 个新的异戊烯基黄酮类化合物，即黧桑宁 A-J（1-10），以及 3 个已知化合物。化合物 8 和 9 促进了脂肪生成，表现为 3T3L1 细胞中脂滴和三酰甘油含量的增加，并诱导脂肪细胞特异性基因 aP2 和 GLUT4 的表达上调。