华桑茎皮的化学成分

Chemical constituents of the stem bark of Morus cathayana.

作者信息

Ni Gang, Zhang Qing-Jian, Wang Ying-Hong, Chen Ruo-Yun, Zheng Zhong-Fei, Yu De-Quan

机构信息

The Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Peking Union Medical College, Ministry of Education, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

出版信息

J Asian Nat Prod Res. 2010 Jun;12(6):505-15. doi: 10.1080/10286020.2010.489817.

DOI:10.1080/10286020.2010.489817

PMID:20552491

Abstract

Phytochemical investigation of the stem bark of Morus cathayana led to the isolation and identification of six new compounds, cathayanons F-J (1-5) and cathayanin A (6), and two known compounds, cathayanins B-C (7-8). Their structures were elucidated by spectroscopic methods. Compounds 1, 2, 3, 5, and 7 exhibited weak activities against five human cancer cell lines, with IC(50) values ranging from 4.7 to 9.8 microg/ml.

摘要

对华桑茎皮进行植物化学研究，从中分离并鉴定出6个新化合物，即华桑酮F-J（1-5）和华桑宁A（6），以及2个已知化合物，即华桑宁B-C（7-8）。通过光谱方法阐明了它们的结构。化合物1、2、3、5和7对5种人类癌细胞系表现出微弱活性，IC50值在4.7至9.8微克/毫升之间。