Piret A, Niset G, Depiesse E, Wyns W, Boeynaems J M, Poortmans J, Degre S
Department of Cardiology, Erasme Hospital, Belgium.
Thromb Res. 1990 Mar 1;57(5):685-95. doi: 10.1016/0049-3848(90)90026-9.
Changes in platelet aggregability during maximal bicycle ergometry were studied in healthy untrained subjects. Ex vivo platelet aggregation in response to ADP and collagen was measured in whole blood by impedance aggregometry or by direct electronic counting in an Ultra-Flo 100 platelet counter. This last method revealed that the platelet aggregation induced by low concentration of ADP (0.5 - 1.0 microM) was significantly enhanced during exercise. The plasma level of beta-thromboglobulin and the urinary excretion of 2,3--dinor-6-keto prostaglandin F1 alpha were also increased. These data indicate that an intense physical exercise enhances the aggregability of human platelets and induces a compensatory increase in prostacyclin biosynthesis.
在健康的未经训练的受试者中，研究了最大运动量自行车测力计运动期间血小板聚集性的变化。通过阻抗聚集法或在Ultra-Flo 100血小板计数器中直接电子计数，测量全血中对ADP和胶原蛋白的体外血小板聚集。最后这种方法显示，在运动期间，低浓度ADP（0.5 - 1.0微摩尔）诱导的血小板聚集显著增强。β-血小板球蛋白的血浆水平和2,3 - 二去甲-6-酮前列腺素F1α的尿排泄量也增加。这些数据表明，剧烈的体育锻炼会增强人类血小板的聚集性，并诱导前列环素生物合成的代偿性增加。
