Office for Study of History of Hellenic Naval Medicine, Naval Hospital of Athens, Greece.
Eur J Intern Med. 2011 Apr;22(2):147-52. doi: 10.1016/j.ejim.2010.10.006. Epub 2010 Nov 16.
This study outlines the major landmarks in the research on scurvy and its relationship to vitamin C. A thorough search including original manuscripts, books and contemporary reviews published in PubMed was conducted using as keywords "scurvy", "vitamin C", and "history of medicine". Observations on scurvy first appear in Egyptian medical scrolls 3500 years ago, and continue through to the discovery of vitamin C and the modern research on the physiological role of ascorbic acid. The observations of great navigators during the 15th and 16th centuries, when scurvy plagued ships' crews, played an important role in clarifying scurvy's etiology. Among the personalities in the history of the disease, James Lind and Albert Szent-Györgyi are most noteworthy, the first for conducting the first clinical trial on the treatment of scurvy with lemon and orange juices, and the second for discovering and identifying vitamin C.
本研究概述了坏血病及其与维生素 C 关系的研究中的主要里程碑。使用“坏血病”、“维生素 C”和“医学史”作为关键词，在 PubMed 中进行了全面的检索，包括原始手稿、书籍和当代评论。对坏血病的观察最早出现在 3500 年前的埃及医学卷轴中，并一直持续到维生素 C 的发现和抗坏血酸的生理作用的现代研究。15 至 16 世纪，当坏血病困扰着船员时，伟大航海家们的观察对阐明坏血病的病因起到了重要作用。在疾病的历史中，詹姆斯·林德和阿尔伯特·森特-哲尔吉是最值得注意的两个人物，前者进行了第一次用柠檬汁和橙汁治疗坏血病的临床试验，后者发现并鉴定了维生素 C。
