一个常见的 HLA-DPA1 变体是汉族人群乙型肝炎病毒清除的主要决定因素。
A common HLA-DPA1 variant is a major determinant of hepatitis B virus clearance in Han Chinese.
机构信息
Basic Research Laboratory, SAIC-Frederick, Maryland, USA.
出版信息
J Infect Dis. 2011 Apr 1;203(7):943-7. doi: 10.1093/infdis/jiq154.
Abstract
A recent genome-wide study showed that the single nucleotide polymorphisms (SNPs) in the HLA-DP region were associated with chronic hepatitis B virus (HBV) infection in Japanese and Thai persons. We tested the effects of HLA-DP SNPs for all major HBV outcomes in Han Chinese (n = 1742): HBV resistance, clearance, chronic infection, cirrhosis, and hepatocellular carcinoma. HLA - DPA1 rs3077 T was strongly associated with decreased risk of chronic HBV infection (odds ratio, .62; P = .001), consistent with the previous report. We showed for the first time to our knowledge that it is a predictor for HBV clearance (odds ratio, 2.41; P < .001). However, rs3077 was not associated with the development of cirrhosis or hepatocellular carcinoma.
摘要
最近的一项全基因组研究表明，HLA-DP 区域的单核苷酸多态性（SNPs）与日本和泰国人群的慢性乙型肝炎病毒（HBV）感染有关。我们检测了 HLA-DP SNPs 对中国汉族人群所有主要 HBV 结局（n=1742）的影响：HBV 耐药、清除、慢性感染、肝硬化和肝细胞癌。HLA-DPA1 rs3077T 与慢性 HBV 感染的风险降低显著相关（比值比，0.62；P=0.001），与之前的报道一致。我们首次证明，它是 HBV 清除的预测因子（比值比，2.41；P<0.001）。然而，rs3077 与肝硬化或肝细胞癌的发生无关。
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