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[卡米诺霉素及其某些衍生物的抗病毒作用]

[Antiviral action of carminomycin and some of its derivatives].

作者信息

Liashenko V A, Shapovalova S P, Aleksander S K, Povarov L S

出版信息

Antibiotiki. 1978 Nov;23(11):1009-15.

PMID:214027
Abstract

Carminomycin was shown to inhibit the development of both the DNA-containing variolovaccine virus and the RNA-containing grippe virus in chick embryos. Comparison of the effects of rubomycin, carminomycin, 14-oxy-carminomycin and carminomycin complex with bovine serum albumin in experiments with chick embryos showed that the inhibitory effect of carminomycin and its derivatives on the development of the grippe virus was much higher than that of rubomycin. The carminomycin derivatives proved to be much more active in this respect than the initial antibiotic. Carminomycin and its derivatives had a therapeutic effect on mice with experimental grippe pneumonia also on their oral use.

摘要

已证明柔红霉素能抑制鸡胚中含DNA的天花疫苗病毒和含RNA的流感病毒的发育。在鸡胚实验中比较了柔红霉素、洋红霉素、14-氧代洋红霉素和洋红霉素与牛血清白蛋白复合物的作用,结果表明洋红霉素及其衍生物对流感病毒发育的抑制作用远高于柔红霉素。事实证明,洋红霉素衍生物在这方面比原始抗生素活性高得多。洋红霉素及其衍生物口服时对患有实验性流感肺炎的小鼠也有治疗作用。

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