Shepelevtseva N G, Belova I P, Vertogradova T P, Gol'dberg L E
Antibiotiki. 1978 Jan;23(1):78-87.
The experiments on albino mice treated with rubomycin, carminomycin or dihydrocarminomycin on its 5-fold intravenous administration in doses equal to similar portions of LD50 of the respective antibiotic on its use in a single dose showed that all the 3 antibiotics induced changes in the myocardium close by their character. The heart affections were evident from swelling of separate muscle fibers, degeneration of the myofibrils, homogenization, vacuolization and resorption of the sarcoplasma, pathological changes in the nuclei, atrophy of some muscle fibers. Rubomycin had the highest cardiotoxic effect. Then followed dihydrocarminomycin and carminomycin. All the antibiotics studied in the experiments with mice had mainly an inhibitory effect on the lymphoid hemopoiesis. The effect of carminomycin was the highest. The animal death during the injections and immediately after administrations of the antibiotics must be due to their suppressing effect on hemopoiesis. The deaths at more remoted periods must be due to the cardiotoxic effect of the antibiotics.
对白化小鼠进行的实验表明，当以相当于各自抗生素单次使用时LD50的五分之一剂量静脉注射柔红霉素、洋红霉素或二氢洋红霉素5次后，所有这3种抗生素在心肌中引起的变化在性质上相近。心脏病变表现为个别肌纤维肿胀、肌原纤维变性、均质化、肌浆空泡化和吸收、细胞核病理变化以及一些肌纤维萎缩。柔红霉素的心脏毒性作用最强，其次是二氢洋红霉素和洋红霉素。在对小鼠的实验中，所研究的所有抗生素对淋巴样造血主要起抑制作用。洋红霉素的作用最强。注射抗生素期间及注射后立即出现的动物死亡必定是由于它们对造血的抑制作用。较晚时期出现的死亡必定是由于抗生素的心脏毒性作用。
