Thaler C J, Behnken L J, Taubert H D
Zentrum für Frauenheilkunde und Geburtshilfe, Johann-Wolfgang-Goethe-Universität, Frankfurt am Main.
Geburtshilfe Frauenheilkd. 1990 Mar;50(3):189-93. doi: 10.1055/s-2007-1026460.
From the immunological point of view, pregnancy is a privileged allograft, with complex mechanisms of adaptation within the maternal immune system preventing rejection. The importance of lymphocytes and their specific subsets for this mechanism is a controversial issue. This study was designed to examine changes within T-cell subsets during uneventful pregnancy and to evaluate their significance by comparison with findings in patients undergoing spontaneous pregnancy loss. When compared to non-pregnant control subjects, normal pregnant women showed significantly decreased numbers for peripheral T-lymphocytes, for helper/inducer-T-cells and for the helper/suppressor-T-cell ratio (T4/T8). In contrast, patients undergoing spontaneous abortion showed a significantly elevated T4/T8-ratio, if compared to normal pregnant women. The clinical relevance of these findings is uncertain. Nevertheless, in individual cases of spontaneous miscarriage, the analysis of T-cell subsets might indicate a possible immunological aetiology.
从免疫学角度来看，妊娠是一种特殊的同种异体移植，母体免疫系统内存在复杂的适应机制以防止排斥反应。淋巴细胞及其特定亚群在这一机制中的重要性是一个有争议的问题。本研究旨在检查正常妊娠期间T细胞亚群的变化，并通过与自然流产患者的结果进行比较来评估其意义。与未怀孕的对照受试者相比，正常孕妇外周血T淋巴细胞、辅助/诱导性T细胞数量以及辅助/抑制性T细胞比值（T4/T8）均显著降低。相反，与正常孕妇相比，自然流产患者的T4/T8比值显著升高。这些发现的临床相关性尚不确定。然而，在个别自然流产病例中，T细胞亚群分析可能提示一种可能的免疫病因。
