Lin Q D
Shanghai Renji Hospital, Shanghai Second Medical University.
Zhonghua Fu Chan Ke Za Zhi. 1990 Sep;25(5):275-7, 315-6.
T-lymphocyte subpopulations were determined by the monoclonal antibodies (OKT3, OKT4, OKT8) in 20 cases of normal pregnancy, 36 cases of pregnancy-induced hypertension (PIH) and 20 cases of normal non-pregnant women. The assaying of ConA-induced suppressor T cell (Ts cell) function was carried out in another 20 cases of late pregnancy, 20 cases of moderate and severe PIH, and 10 cases of normal non-pregnant women. The results showed: the percentage of Ts cell increased significantly and the ratios of Th/Ts decreased significantly during normal pregnancy as compared with normal non-pregnant women. As compared with the late pregnant women, a lowering of Ts cell and elevating ratio of Th/Ts were found in PIH cases with statistical significance in severe PIH. A decrease of Ts cell function was also seen in moderate and severe PIH cases. All these findings suggest that the changes of Ts cell in amount and function may play an important role in maintaining normal pregnancy and in the pathogenesis of PIH.
采用单克隆抗体（OKT3、OKT4、OKT8）对20例正常孕妇、36例妊娠高血压综合征（PIH）患者及20例正常未孕妇女的T淋巴细胞亚群进行检测。另对20例晚期妊娠妇女、20例中重度PIH患者及10例正常未孕妇女进行刀豆蛋白A诱导的抑制性T细胞（Ts细胞）功能检测。结果显示：与正常未孕妇女相比，正常妊娠期间Ts细胞百分比显著升高，Th/Ts比值显著降低。与晚期妊娠妇女相比，PIH患者Ts细胞降低，Th/Ts比值升高，重度PIH具有统计学意义。中重度PIH患者Ts细胞功能也降低。所有这些结果提示，Ts细胞数量和功能的变化可能在维持正常妊娠及PIH发病机制中起重要作用。
