Sammartino Gilberto, Marenzi Gaetano, Cioffi Iacopo, Teté Stefano, Mortellaro Carmen
Department of Odontostomatologic and Maxillo-Facial Sciences, University of Naples Federico II, Faculty of Medicine, Naples, Italy.
J Craniofac Surg. 2011 Mar;22(2):443-5. doi: 10.1097/SCS.0b013e318207b59b.
In this multicenter study, submerged implants were prospectively followed to evaluate their long-term prognosis in irradiated patients. In a total of 77 patients treated for oral or neck cancer, 188 implants were consecutively placed. After a healing period, the successfully integrated implants were restored with 69 removable and 38 fixed restorations. The implants cumulative survival and success rates were evaluated over a period of at least 36 months. In addition, cumulative success rates were calculated for implant subgroups divided per implant site (mandible or maxilla), radiation dosage, and the time interval between the last irradiation and implant placement. During the healing period, 20 implants did not successfully integrate, whereas 168 implants were classified as success (including both survival and success rates). The analysis of implant subgroups showed slightly more favorable cumulative success rate for mandibular implants (98.4%) compared with maxillary implants (57.1%) and clearly better success rate for a radiation dosage minor of 50-Gy doses. A time greater than 12 months as interval between last irradiation and implant placement seems not to promote better clinical results.
在这项多中心研究中，对潜入式种植体进行前瞻性随访，以评估其在接受放疗患者中的长期预后。在总共77例接受口腔或颈部癌症治疗的患者中，连续植入了188颗种植体。经过愈合期后，成功整合的种植体采用69个可摘修复体和38个固定修复体进行修复。在至少36个月的时间内评估种植体的累积生存率和成功率。此外，还计算了按种植部位（下颌骨或上颌骨）、放射剂量以及最后一次放疗与种植体植入之间的时间间隔划分的种植体亚组的累积成功率。在愈合期，20颗种植体未成功整合，而168颗种植体被归类为成功（包括生存率和成功率）。种植体亚组分析显示，下颌种植体的累积成功率（98.4%）略高于上颌种植体（57.1%），放射剂量小于50 Gy时成功率明显更高。最后一次放疗与种植体植入之间的时间间隔大于12个月似乎并不能带来更好的临床效果。
