University College London Centre for Nephrology, Royal Free Hospital, London, UK.
Kidney Int. 2011 Apr;79(7):699-701. doi: 10.1038/ki.2010.558.
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis are predominantly diseases of older patients, frequently involving the kidney. Bomback and colleagues studied disease outcome in very elderly patients (>80 years old) with ANCA-associated renal disease. Immunosuppression resulted in lower rates of end-stage renal disease at 1 year and lower mortality at 2 years. Although these data suggest we should treat these elderly patients with immunosuppression, the criteria for patient selection and the dosage and duration of the treatment regimen need to be established.
抗中性粒细胞胞质抗体（ANCA）相关性血管炎主要发生于老年患者，常累及肾脏。Bomback 及其同事研究了年龄非常大的（>80 岁）患有 ANCA 相关性肾脏疾病的患者的疾病结局。免疫抑制治疗可降低 1 年时的终末期肾病发生率和 2 年时的死亡率。尽管这些数据提示我们应该对这些老年患者进行免疫抑制治疗，但需要确定患者选择的标准以及治疗方案的剂量和持续时间。
