Stuber Kent, Sajko Sandy, Kristmanson Kevyn
Canadian Memorial Chiropractic College; Private Practice, Calgary Alberta.
J Can Chiropr Assoc. 2011 Mar;55(1):47-55.
Nutritional supplements are commonly used for a variety of musculoskeletal conditions, including knee and hip degenerative joint disease. Although these supplements are occasionally recommended for patients with degenerative disc disease and spinal degenerative joint disease, the evidence supporting this use is unknown.
To systematically search and assess the quality of the literature on the use of glucosamine, chondroitin sulfate, and methylsulfonylmethane for the treatment of spinal osteoarthritis / degenerative joint disease, and degenerative disc disease.
The Index of Chiropractic Literature, AMED, Medline, and CINAHL were searched for randomized controlled trials in English from 1984 to July 2009.
Data from studies meeting the inclusion criteria was extracted and reviewed by three reviewers. The Jadad scale was used to assess study quality. No attempts were made at meta-analysis due to variation in study design.
Two articles met the inclusion criteria. One study was found to have good quality but reported negative results for the supplemented group compared with placebo, the other study had low quality but reported significant positive results for the supplemented group when compared with a no intervention control group.
There was little literature found to support the use of common nutritional supplements for spinal degeneration, making it difficult to determine whether clinicians should recommend them.
营养补充剂常用于多种肌肉骨骼疾病，包括膝关节和髋关节退行性关节病。尽管这些补充剂偶尔也会被推荐给椎间盘退变疾病和脊柱退行性关节病患者，但支持这种用法的证据尚不明确。
系统检索和评估有关氨基葡萄糖、硫酸软骨素和二甲基砜用于治疗脊柱骨关节炎/退行性关节病以及椎间盘退变疾病的文献质量。
检索了脊椎按摩疗法文献索引、联合和补充医学数据库（AMED）、医学索引数据库（Medline）以及护理学与健康领域数据库（CINAHL），以查找1984年至2009年7月期间的英文随机对照试验。
由三位评审员提取并审查符合纳入标准的研究数据。采用雅达量表评估研究质量。由于研究设计存在差异，未进行荟萃分析。
两篇文章符合纳入标准。一项研究质量良好，但与安慰剂组相比，补充剂组报告了阴性结果；另一项研究质量较低，但与无干预对照组相比，补充剂组报告了显著的阳性结果。
几乎没有文献支持使用常见营养补充剂治疗脊柱退变，因此难以确定临床医生是否应推荐使用这些补充剂。
