CIIMAR-Centre for Marine Environmental Research, Rua dos Bragas 289, Porto, Portugal.
Bull Environ Contam Toxicol. 2011 Apr;86(4):379-83. doi: 10.1007/s00128-011-0234-y. Epub 2011 Mar 15.
The purpose of this research was to assess the effects of exposure to selected PAHs (phenanthrene, pyrene, and fluorene) on brain acetylcholinesterase (AChE) in juvenile gilthead seabream (Sparus aurata) in short term in vivo experiments. The measured brain AChE activity was within the same range (110-200 nmol min(-1) mg prot(-1)) in all the considered treatment conditions and in the control. The only statistically significant difference in AChE activity with respect to the control group was its induction in response to the lowest tested pyrene concentration in one of two replicated studies. These results suggest that exposure to PAHs does not appreciably affect brain AChE activity.
本研究旨在评估暴露于选定的多环芳烃（菲、芘和荧蒽）对幼年金枪鱼脑乙酰胆碱酯酶（AChE）的短期体内实验影响。在所有考虑的处理条件和对照组中，测量的脑 AChE 活性都在相同的范围内（110-200nmol min(-1)mg prot(-1))。与对照组相比，AChE 活性唯一具有统计学意义的差异是在两项重复研究中的一项中，对最低测试浓度的芘的反应诱导。这些结果表明，暴露于多环芳烃不会明显影响大脑乙酰胆碱酯酶的活性。
