Department of Experimental Medicine and Biotechnology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Adv Clin Chem. 2011;53:139-53.
Diabetes mellitus is a known predisposition factor for tuberculosis. However, the cause of such interrelationship is incompletely understood. Diabetes mellitus is characterized by hyperglycemia. Interestingly, glucose has been shown to stimulate NADPH oxidase, the key enzyme involved with respiratory burst in monocytes and macrophages. This glucose-induced genesis of reactive oxygen species via respiratory burst is contrary to the survival strategy of Mycobacterium tuberculosis as an intracellular pathogen in phagocytic cells. To address this paradox, diabetes and tuberculosis are reviewed at the molecular level.
糖尿病是结核病的已知易感因素。然而，这种相互关系的原因尚不完全清楚。糖尿病的特征是高血糖。有趣的是，葡萄糖已被证明能刺激 NADPH 氧化酶，这是与单核细胞和巨噬细胞呼吸爆发有关的关键酶。这种通过呼吸爆发产生的葡萄糖诱导的活性氧生成与结核分枝杆菌作为吞噬细胞内病原体的生存策略相悖。为了解决这一矛盾，我们从分子水平上对糖尿病和结核病进行了综述。
