在格鲁吉亚，糖尿病与龋齿、涂片分级及耐多药结核病相关。
Diabetes mellitus is associated with cavities, smear grade, and multidrug-resistant tuberculosis in Georgia.
作者信息
Magee M J, Kempker R R, Kipiani M, Gandhi N R, Darchia L, Tukvadze N, Howards P P, Narayan K M V, Blumberg H M
机构信息
Division of Epidemiology and Biostatistics, School of Public Health, Georgia State University, Atlanta, USA; Departments of Epidemiology and Global Health, Rollins School of Public Health, Emory University, Atlanta, USA.
Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
出版信息
Int J Tuberc Lung Dis. 2015 Jun;19(6):685-92. doi: 10.5588/ijtld.14.0811.
SETTING
National tuberculosis (TB) treatment facility in the country of Georgia.
OBJECTIVE
To determine the prevalence of diabetes mellitus (DM) and pre-DM among patients with TB using glycosylated-hemoglobin (HbA1c), and to estimate the association between DM and clinical characteristics and response to anti-tuberculosis treatment.
DESIGN
A cohort study was conducted from 2011 to 2014 at the National Centre for TB and Lung Disease in Tbilisi. Patients aged ⩾ 35 years with pulmonary TB were included. HbA1c was used to define DM (⩾ 6.5%), pre-DM (⩾ 5.7-6.4%), and no DM (<5.7%). Interviews and medical chart abstraction were performed. Regression analyses estimated associations between DM and 1) baseline TB characteristics and 2) anti-tuberculosis treatment outcomes.
RESULTS
A total of 318 newly diagnosed patients with TB were enrolled. The prevalence of DM and pre-DM was 11.6% and 16.4%, respectively. In multivariable analyses, patients with TB-DM had more cavitation (adjusted OR [aOR] 2.26), higher smear grade (aOR 2.37), and more multidrug-resistant TB (MDR-TB) (aOR 2.27) than patients without DM. The risk of poor anti-tuberculosis treatment outcomes was similar among patients with and those without DM (28.1% vs. 23.6%).
CONCLUSION
DM and pre-DM were common among adults with newly diagnosed pulmonary TB in Tbilisi, Georgia, and DM was associated with more clinical symptoms, and MDR-TB, at presentation.
背景
格鲁吉亚国家结核病治疗机构。
目的
使用糖化血红蛋白（HbA1c）测定结核病患者中糖尿病（DM）和糖尿病前期（pre-DM）的患病率，并评估DM与临床特征及抗结核治疗反应之间的关联。
设计
2011年至2014年在第比利斯的国家结核病和肺部疾病中心进行了一项队列研究。纳入年龄≥35岁的肺结核患者。使用HbA1c定义DM（≥6.5%）、pre-DM（≥5.7 - 6.4%）和非DM（<5.7%）。进行了访谈和病历摘要分析。回归分析评估了DM与1）基线结核病特征和2）抗结核治疗结果之间的关联。
结果
共纳入318例新诊断的结核病患者。DM和pre-DM的患病率分别为11.6%和16.4%。在多变量分析中，与无DM的患者相比，结核病合并DM的患者有更多空洞形成（调整后比值比[aOR] 2.26）、更高的涂片分级（aOR 2.37）和更多的耐多药结核病（MDR-TB）（aOR 2.27）。有DM和无DM的患者抗结核治疗效果不佳的风险相似（28.1%对23.6%）。
结论
在格鲁吉亚第比利斯，新诊断的成年肺结核患者中DM和pre-DM很常见，且DM与更多的临床症状以及就诊时的MDR-TB相关。
Zotero 插件