钯催化的偕二烯醇的三组分转化：一种区域和立体选择性合成 1,5-氨基醇的方法。
Palladium-catalyzed three-component transformation of homoallenols: a regio- and stereoselective route to 1,5-amino alcohols.
机构信息
Centre for Synthesis and Chemical Biology (CSCB), School of Chemistry and Chemical Biology, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland.
出版信息
J Org Chem. 2011 May 6;76(9):3536-8. doi: 10.1021/jo1025628. Epub 2011 Mar 28.
PMID:21405098
Abstract
A palladium-catalyzed three-component transformation of enantioenriched homoallenols with aryl halides and amines has been developed to selectively afford (Z)-configured 1,5-amino alcohols in good-to-excellent yields without any epimerization.
摘要
钯催化的对映富集的同多烯醇与芳基卤化物和胺的三组分转化反应已经被开发出来，可以在没有任何外消旋化的情况下，以良好至优异的收率选择性地得到（Z）构型的 1,5-氨基醇。
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