Section of Critical Care Medicine and Infectious Diseases, Health Sciences Centre and St Boniface Hospital, University of Manitoba, Winnipeg, Manitoba, Canada.
J Antimicrob Chemother. 2011 May;66(5):959-63. doi: 10.1093/jac/dkr090. Epub 2011 Mar 15.
The need for early antimicrobial therapy is well established for life-threatening bacterial and fungal infections including meningitis and sepsis/septic shock. However, a link between the outcome of serious viral infections and delays in antiviral therapy is not as well recognized. Recently, with the occurrence of the influenza A/H1N1 pandemic of 2009, a large body of data regarding this issue has become available. Studies analysing data from this pandemic have consistently shown that delays in initiation of antiviral therapy following symptom onset are significantly associated with disease severity and death. Optimal survival and minimal disease severity appear to result when antivirals are started as soon as possible after symptom onset.
对于危及生命的细菌和真菌感染，包括脑膜炎和败血症/感染性休克，早期使用抗菌药物治疗是非常必要的。然而，严重病毒感染的治疗延迟与治疗结果之间的关系并没有得到充分认识。最近，随着 2009 年甲型 H1N1 流感大流行的发生，大量关于这个问题的数据已经出现。对这些大流行数据进行分析的研究一致表明，从症状出现到开始抗病毒治疗的延迟与疾病严重程度和死亡显著相关。在症状出现后尽快开始抗病毒治疗似乎可以实现最佳的生存和最小的疾病严重程度。
