Institut für Physik, Johannes Gutenberg-Universität Mainz, Staudinger Weg 7, 55128 Mainz, Germany.
J Phys Condens Matter. 2011 Jan 26;23(3):033101. doi: 10.1088/0953-8984/23/3/033101. Epub 2010 Dec 10.
In the last decade, a new class of proteins has emerged that contain a topological knot in their backbone. Although these structures are rare, they nevertheless challenge our understanding of protein folding. In this review, we provide a short overview of topologically knotted proteins with an emphasis on newly discovered structures. We discuss the current knowledge in the field, including recent developments in both experimental and computational studies that have shed light on how these intricate structures fold.
在过去的十年中，出现了一类新的蛋白质，它们的骨架中含有拓扑结。尽管这些结构很罕见，但它们仍然挑战了我们对蛋白质折叠的理解。在这篇综述中，我们简要概述了拓扑打结蛋白，并重点介绍了新发现的结构。我们讨论了该领域的现有知识，包括实验和计算研究方面的最新进展，这些进展揭示了这些复杂结构的折叠方式。
