E-health Unit, Research Department of Primary Care and Population Health, University College London, London, United Kingdom.
PLoS One. 2011 Mar 9;6(3):e14740. doi: 10.1371/journal.pone.0014740.
Interventions delivered via the Internet have the potential to address the problem of hazardous alcohol consumption at minimal incremental cost, with potentially major public health implications. It was hypothesised that providing access to a psychologically enhanced website would result in greater reductions in drinking and related problems than giving access to a typical alcohol website simply providing information on potential harms of alcohol. DYD-RCT Trial registration: ISRCTN 31070347.
METHODOLOGY/PRINCIPAL FINDINGS: A two-arm randomised controlled trial was conducted entirely on-line through the Down Your Drink (DYD) website. A total of 7935 individuals who screened positive for hazardous alcohol consumption were recruited and randomized. At entry to the trial, the geometric mean reported past week alcohol consumption was 46.0 (SD 31.2) units. Consumption levels reduced substantially in both groups at the principal 3 month assessment point to an average of 26.0 (SD 22.3) units. Similar changes were reported at 1 month and 12 months. There were no significant differences between the groups for either alcohol consumption at 3 months (intervention: control ratio of geometric means 1.03, 95% CI 0.97 to 1.10) or for this outcome and the main secondary outcomes at any of the assessments. The results were not materially changed following imputation of missing values, nor was there any evidence that the impact of the intervention varied with baseline measures or level of exposure to the intervention.
CONCLUSIONS/SIGNIFICANCE: Findings did not provide support for the hypothesis that access to a psychologically enhanced website confers additional benefit over standard practice and indicate the need for further research to optimise the effectiveness of Internet-based behavioural interventions. The trial demonstrates a widespread and potentially sustainable demand for Internet based interventions for people with hazardous alcohol consumption, which could be delivered internationally.
Controlled-Trials.com ISRCTN31070347.
通过互联网提供的干预措施有可能以最小的增量成本解决危险饮酒问题，这可能会产生重大的公共卫生影响。研究假设，提供一个经过心理强化的网站的访问权限，将比仅仅提供酒精潜在危害信息的典型酒精网站更能减少饮酒和相关问题。DYD-RCT 试验注册：ISRCTN31070347。
方法/主要发现：这项完全在网上进行的双臂随机对照试验是通过 Down Your Drink（DYD）网站进行的。共有 7935 名筛查出有危险饮酒的人被招募并随机分组。在试验开始时，报告过去一周的平均酒精摄入量为 46.0（SD31.2）单位。两组在主要的 3 个月评估点，饮酒量都大大减少，平均为 26.0（SD22.3）单位。在 1 个月和 12 个月时也报告了类似的变化。在 3 个月时，两组的酒精摄入量（干预组与对照组的几何均数比为 1.03，95%CI 0.97 至 1.10）或任何评估的主要次要结果都没有显著差异。在对缺失值进行插补后，结果并没有发生实质性变化，也没有证据表明干预的影响随基线测量值或干预暴露水平而变化。
结论/意义：研究结果不支持这样的假设，即访问一个经过心理强化的网站会比标准做法带来额外的好处，并表明需要进一步研究，以优化基于互联网的行为干预措施的有效性。该试验表明，对于有危险饮酒问题的人来说，基于互联网的干预措施有广泛的、潜在可持续的需求，这种干预措施可以在国际上推广。
Controlled-Trials.com ISRCTN31070347。
