Simpson Tracy, Sistad Rebecca, Brooks Jack T, Newberger Noam G, Livingston Nicholas A
Center of Excellence in Substance Addiction Treatment & Education, VA Puget Sound Healthcare System, Seattle, WA, USA.
University of Washington School of Medicine, Seattle, WA, USA.
Drug Alcohol Depend Rep. 2022 Nov 17;5:100116. doi: 10.1016/j.dadr.2022.100116. eCollection 2022 Dec.
Findings from a person-level meta-analysis of online alcohol intervention trials suggest that women disproportionately seek out such interventions (Riper et al., 2018). Although women may be a "hidden population" that is particularly drawn to online alcohol interventions, trial design features may explain women's apparent over-representation in these trials.
This systematic review examined associations between gender-tailored recruitment/inclusion criteria and proportions of women enrolled in online alcohol intervention trials, evaluated whether community samples have greater proportions of women than clinical samples, and compared country-specific average proportions of women in trials to country-specific proportions of women with Alcohol Use Disorder (AUD).
Forty-four trials met inclusion/exclusion criteria, 34 community samples and 10 drawn from clinical settings; 4 studies included U.S. veterans and were examined separately. The average proportion of community-recruited women across the studies was 51.20% and the average proportion of clinically-recruited women was 35.81%, a difference that was statistically significant. Across the countries with relevant trials, the expected proportion of those with AUD who are women is 27.1% (World Population Review, 2022). Only 2 studies used targeted recruitment for women so no between-group tests were conducted. There was not a statistically significant difference in the proportion of women across trials that did and did not use gender-tailored alcohol inclusion criteria.
Results from this systematic review suggest that study design factors do not account for the marked over-representation of women in online alcohol interventions, indicating that women are indeed a "hidden population" whose needs should be understood and accommodated.
一项针对在线酒精干预试验的个体水平荟萃分析结果表明,女性寻求此类干预的比例过高(里珀等人,2018年)。尽管女性可能是特别受在线酒精干预吸引的“隐性人群”,但试验设计特征可能解释了女性在这些试验中明显的过度代表性。
本系统评价研究了性别针对性招募/纳入标准与在线酒精干预试验中女性入组比例之间的关联,评估社区样本中的女性比例是否高于临床样本,并将试验中特定国家的女性平均比例与特定国家酒精使用障碍(AUD)女性的比例进行比较。
44项试验符合纳入/排除标准,34项为社区样本,10项来自临床环境;4项研究纳入了美国退伍军人并单独进行了检查。各研究中社区招募女性的平均比例为51.20%,临床招募女性的平均比例为35.81%,差异具有统计学意义。在有相关试验的国家中,AUD女性的预期比例为27.1%(世界人口评论,2022年)。只有2项研究针对女性进行了定向招募,因此未进行组间测试。在使用和未使用性别针对性酒精纳入标准的试验中,女性比例没有统计学上的显著差异。
本系统评价结果表明,研究设计因素无法解释女性在在线酒精干预中明显的过度代表性,这表明女性确实是一个“隐性人群”,其需求应得到理解和满足。