对慢性疲劳综合征患者中 XMRV 的存在及其血清学反应的调查。

Jefferiss Research Trust Laboratories, Section of Infectious Diseases, Wright-Fleming Institute, Faculty of Medicine, Imperial College London, London, United Kingdom.

PLoS One. 2011 Mar 9;6(3):e17592. doi: 10.1371/journal.pone.0017592.

The novel human gammaretrovirus xenotropic murine leukemia virus-related virus (XMRV), originally described in prostate cancer, has also been implicated in chronic fatigue syndrome (CFS). When later reports failed to confirm the link to CFS, they were often criticised for not using the conditions described in the original study. Here, we revisit our patient cohort to investigate the XMRV status in those patients by means of the original PCR protocol which linked the virus to CFS. In addition, sera from our CFS patients were assayed for the presence of xenotropic virus envelope protein, as well as a serological response to it. The results further strengthen our contention that there is no evidence for an association of XMRV with CFS, at least in the UK.

新型人类γ逆转录病毒嗜性鼠白血病病毒相关病毒（XMRV）最初在前列腺癌中被描述，也与慢性疲劳综合征（CFS）有关。当后来的报告未能证实与 CFS 的联系时，它们经常因没有使用原始研究中描述的条件而受到批评。在这里，我们重新研究了我们的患者队列，通过与 CFS 相关的原始 PCR 方案来调查 XMRV 在这些患者中的状态。此外，我们还检测了来自 CFS 患者的血清中是否存在嗜性病毒包膜蛋白，以及对其的血清学反应。结果进一步证实了我们的观点，即至少在英国，没有证据表明 XMRV 与 CFS 有关。