小核核糖核蛋白U1A和U2B''与其同源RNA之间相互作用特异性的主要决定因素。
Major determinants of the specificity of interaction between small nuclear ribonucleoproteins U1A and U2B'' and their cognate RNAs.
作者信息
Scherly D, Boelens W, Dathan N A, van Venrooij W J, Mattaj I W
机构信息
European Molecular Biology Laboratory, Heidelberg, FRG.
出版信息
Nature. 1990 Jun 7;345(6275):502-6. doi: 10.1038/345502a0.
DOI:10.1038/345502a0
PMID:2140872
Abstract
The basis of the specificity of interaction of U1 and U2 small nuclear (sn)RNAs and their cognate binding proteins, U1A and U2B'', has been examined. The U1A protein recognizes U1 snRNA on its own, whereas U2B'' binds specifically to U2 snRNA only in the presence of a second protein, U2A'. Exchange of two nucleotides between the two RNAs or of eight amino acids between the two proteins reverses binding specificity.
摘要
U1和U2小核（sn）RNA与其同源结合蛋白U1A和U2B''相互作用特异性的基础已得到研究。U1A蛋白自身就能识别U1 snRNA，而U2B''只有在第二种蛋白U2A'存在时才会特异性结合U2 snRNA。两种RNA之间交换两个核苷酸或两种蛋白之间交换八个氨基酸会使结合特异性发生逆转。
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