Department of Chemistry, University of Cyprus, P.O. Box 20537, 1678 Nicosia, Cyprus.
Org Biomol Chem. 2011 May 7;9(9):3122-5. doi: 10.1039/c1ob05167a. Epub 2011 Mar 15.
Stille and Suzuki-Miyaura reactions of 7-iodo-1,3-diphenyl-1,4-dihydro-1,2,4-benzotriazin-4-yl are presented as rare examples of cross-coupling reactions with stable organic radicals. Both the Stille and Suzuki-Miyaura reactions are in most cases high yielding but the latter are cleaner while the former are faster and are accompanied by 1,3-diphenyl-1,2,4-benzotriazin-7(H)-one as by-product. A range of 7-aryl and 7-heteroaryl-1,2,4-benzotriazinyls have been synthesized and characterized using standard spectroscopic and spectrometric means.
7-碘-1,3-二苯基-1,4-二氢-1,2,4-苯并三嗪-4-基的 Stille 和 Suzuki-Miyaura 反应是稳定有机自由基交叉偶联反应的罕见实例。Stille 和 Suzuki-Miyaura 反应在大多数情况下产率都很高，但后者的副产物较少，而前者的反应速度更快，且伴有 1,3-二苯基-1,2,4-苯并三嗪-7(H)-酮生成。使用标准的光谱和光谱学方法，已经合成并表征了一系列 7-芳基和 7-杂芳基-1,2,4-苯并三嗪基。
