Arif Muhammad, Iqbal Zafar
Department of Ophthalmology, Khyber Teaching Hospital, Peshawar, Pakistan.
J Ayub Med Coll Abbottabad. 2010 Jan-Mar;22(1):109-11.
The purpose of this study was to evaluate the frequency of metastatic retinoblastoma on initial presentation.
Prospective study.
Supra Regional Centre for Retinoblastoma, Department of Ophthalmology, Khyber Teaching Hospital Peshawar Pakistan from 1st July 1999 to 31st January 2003.
Data was collected from 80 registered Retinoblastoma patients admitted and examined under anaesthesia for tumours assessment. Diagnosis was supported with the help of CT scan and confirmed by histopathology of the enucleated specimen for evidence of optic nerve invasion by the tumour.
Twenty (25%) patients were presenting as Metastasis on initial presentation. Mean age was 3.5 years, range was 7 months to 12 years. Out of these 20 patients with metastasis, 10 were male and 10 were female. Eighteen (90%) of them were from lower socio-economic group.
Failure in early diagnosis of retinoblastoma, advance age and unilateral disease are associated with extraocular spread; this tragic scenario can be prevented best be early detection and prompt treatment plan implementation.
本研究旨在评估初诊时转移性视网膜母细胞瘤的发生率。
前瞻性研究。
1999年7月1日至2003年1月31日，位于巴基斯坦白沙瓦开伯尔教学医院眼科的视网膜母细胞瘤超区域中心。
收集80例登记在册的视网膜母细胞瘤患者的数据，这些患者入院并在麻醉下接受检查以评估肿瘤情况。借助CT扫描辅助诊断，并通过摘除标本的组织病理学检查确诊，以确定肿瘤是否侵犯视神经。
20例（25%）患者初诊时即表现为转移。平均年龄为3.5岁，范围为7个月至12岁。在这20例发生转移的患者中，10例为男性，10例为女性。其中18例（90%）来自社会经济地位较低的群体。
视网膜母细胞瘤早期诊断失败、年龄较大和单侧患病与眼外扩散有关；通过早期检测和及时实施治疗方案，这种悲剧情况可以得到最佳预防。
