Ben-Rafael Z, Bider D, Menashe Y, Maymon R, Zolti M, Mashiach S
Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Tel-Hashomer, Israel.
Fertil Steril. 1990 Jun;53(6):1091-4. doi: 10.1016/s0015-0282(16)53592-4.
Ovarian cysts are a common complication of GnRH-a administration. We followed 98 patients who were suppressed with GnRH-a before ovarian stimulation with hMG for IVF treatment. Approximately 20% of the patients receiving GnRH-a during the follicular or luteal phase had developed ovarian cysts. However, the number of cysts per patient was significantly higher in the follicular phase compared with luteal phase. Systematic aspiration of those cysts under local anesthesia permitted the start of ovarian stimulation with hMG as scheduled on day 16 after GnRH-a administration. Follicular fluid content of the cysts revealed similar levels of steroids to those in normal follicles. These cysts contained few cells and no egg. In vitro fertilization treatment was more successful in patients whose cysts were aspirated during the luteal phase than in those with cysts during the follicular phase. We concluded that luteal phase cysts are more benign than follicular phase cysts, and it is possible that they represent an enlargement of pre-existing corpora lutea.
卵巢囊肿是 GnRH-a 给药后的常见并发症。我们对 98 例在使用 hMG 进行卵巢刺激以进行 IVF 治疗前接受 GnRH-a 抑制的患者进行了随访。在卵泡期或黄体期接受 GnRH-a 的患者中，约 20% 出现了卵巢囊肿。然而，与黄体期相比，卵泡期每位患者的囊肿数量明显更高。在局部麻醉下对这些囊肿进行系统抽吸后，可在 GnRH-a 给药后第 16 天按计划开始用 hMG 进行卵巢刺激。囊肿的卵泡液成分显示，其类固醇水平与正常卵泡相似。这些囊肿细胞很少，没有卵子。黄体期囊肿抽吸患者的体外受精治疗比卵泡期囊肿患者更成功。我们得出结论，黄体期囊肿比卵泡期囊肿更良性，它们可能是已存在的黄体的增大。
