Ron-El R, Herman A, Golan A, van der Ven H, Caspi E, Diedrich K
Department of Obstetrics and Gynecology, Assaf Harofeh Medical Center, Tel Aviv University, Zerifin, Israel.
Fertil Steril. 1990 Aug;54(2):233-7. doi: 10.1016/s0015-0282(16)53695-4.
Long-acting GnRH-a (D-Trp6 microcapsules, 3.2 mg) was intramuscularly injected, either in early follicular phase (group A) or midluteal phase (group B). Two hundred sixteen cycles were randomly allocated. Ovarian suppression was significantly more prompt in group B. Follicle cysts were diagnosed in 19% and 16% of groups A and B, respectively; their appearance and regression were significantly more rapid in group B cycles. More ampules of human menopausal gonadotropin were needed in group B. The number of oocytes retrieved was not significantly different between the groups. However, in group A more mature oocytes and more embryos with good morphology were achieved in the patients. Cancellation rate was 2.8% in groups A and B. Pregnancy rate and outcome were similar in both groups.
长效促性腺激素释放激素激动剂（D-色氨酸6微囊，3.2毫克）在卵泡早期（A组）或黄体中期（B组）进行肌肉注射。216个周期被随机分配。B组的卵巢抑制明显更迅速。A组和B组分别有19%和16%的患者被诊断出卵泡囊肿；B组周期中囊肿的出现和消退明显更快。B组需要更多的人绝经期促性腺激素安瓿。两组间获取的卵母细胞数量无显著差异。然而，A组患者获得了更多成熟卵母细胞和形态良好的胚胎。A组和B组的取消率均为2.8%。两组的妊娠率和结局相似。
