相互作用组网络与人类疾病。
Interactome networks and human disease.
机构信息
Center for Cancer Systems Biology and Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
出版信息
Cell. 2011 Mar 18;144(6):986-98. doi: 10.1016/j.cell.2011.02.016.
Abstract
Complex biological systems and cellular networks may underlie most genotype to phenotype relationships. Here, we review basic concepts in network biology, discussing different types of interactome networks and the insights that can come from analyzing them. We elaborate on why interactome networks are important to consider in biology, how they can be mapped and integrated with each other, what global properties are starting to emerge from interactome network models, and how these properties may relate to human disease.
摘要
复杂的生物系统和细胞网络可能是大多数基因型到表型关系的基础。在这里，我们回顾了网络生物学的基本概念，讨论了不同类型的互作网络以及分析它们可以获得的见解。我们详细阐述了互作网络在生物学中为什么很重要，它们如何相互映射和整合，从互作网络模型中开始出现哪些全局性质，以及这些性质如何与人类疾病相关。
相似文献
1
Interactome networks and human disease.
Cell. 2011 Mar 18;144(6):986-98. doi: 10.1016/j.cell.2011.02.016.
2
Information flow analysis of interactome networks.
PLoS Comput Biol. 2009 Apr;5(4):e1000350. doi: 10.1371/journal.pcbi.1000350. Epub 2009 Apr 10.
3
Estimating dispensable content in the human interactome.
Nat Commun. 2019 Jul 19;10(1):3205. doi: 10.1038/s41467-019-11180-2.
4
A paradigm shift in medicine: A comprehensive review of network-based approaches.
Biochim Biophys Acta Gene Regul Mech. 2020 Jun;1863(6):194416. doi: 10.1016/j.bbagrm.2019.194416. Epub 2019 Aug 2.
5
Weighted Protein Interaction Network Analysis of Frontotemporal Dementia.
J Proteome Res. 2017 Feb 3;16(2):999-1013. doi: 10.1021/acs.jproteome.6b00934. Epub 2017 Jan 12.
6
Network-based methods for human disease gene prediction.
Brief Funct Genomics. 2011 Sep;10(5):280-93. doi: 10.1093/bfgp/elr024. Epub 2011 Jul 15.
7
Gene co-expression in the interactome: moving from correlation toward causation via an integrated approach to disease module discovery.
NPJ Syst Biol Appl. 2021 Jan 21;7(1):3. doi: 10.1038/s41540-020-00168-0.
8
Edgotype: a fundamental link between genotype and phenotype.
Curr Opin Genet Dev. 2013 Dec;23(6):649-57. doi: 10.1016/j.gde.2013.11.002. Epub 2013 Nov 26.
9
Interactome mapping for analysis of complex phenotypes: insights from benchmarking binary interaction assays.
Proteomics. 2012 May;12(10):1499-518. doi: 10.1002/pmic.201100598.
10
Network Biology Approaches to Identify Molecular and Systems-Level Differences Between Salmonella Pathovars.
Methods Mol Biol. 2019;1918:265-273. doi: 10.1007/978-1-4939-9000-9_21.
引用本文的文献
1
Unraveling cooperative and competitive interactions within protein triplets in the human interactome.
Sci Rep. 2025 Sep 15;15(1):32548. doi: 10.1038/s41598-025-19264-4.
2
Roadmap for a Systems Biology Initiative in Iran.
J Med Signals Sens. 2025 Sep 1;15:26. doi: 10.4103/jmss.jmss_66_24. eCollection 2025.
3
diaPASEF-Powered Chemoproteomics Enables Deep Kinome Interaction Profiling.
J Proteome Res. 2025 Aug 27. doi: 10.1021/acs.jproteome.5c00109.
4
Large-scale protein interactome reveals lineage-specific genes driving plant-parasitic nematode adaptive innovations.
Sci Adv. 2025 Aug 15;11(33):eadt5107. doi: 10.1126/sciadv.adt5107.
5
Introduction to correlation networks: Interdisciplinary approaches beyond thresholding.
Phys Rep. 2025 Aug 21;1136:1-39. doi: 10.1016/j.physrep.2025.06.002. Epub 2025 Jun 30.
6
Do We Know Enough About the Safety Profile of Silver Nanoparticles in Oncology? A Focus on Novel Methods and Approaches.
Int J Mol Sci. 2025 Jun 2;26(11):5344. doi: 10.3390/ijms26115344.
7
Network architecture of transcriptomic stress responses in zebrafish embryos.
PLoS Comput Biol. 2025 Jun 11;21(6):e1013164. doi: 10.1371/journal.pcbi.1013164. eCollection 2025 Jun.
8
CHCHD4 Oxidoreductase Activity: A Comprehensive Analysis of the Molecular, Functional, and Structural Properties of Its Redox-Regulated Substrates.
Molecules. 2025 May 10;30(10):2117. doi: 10.3390/molecules30102117.
9
A quantitative comparison of the deleteriousness of missense and nonsense mutations using the structurally resolved human protein interactome.
Protein Sci. 2025 Jun;34(6):e70155. doi: 10.1002/pro.70155.
10
Conjunctival MicroRNA Expression Signature in Primary Sjögren's Syndrome Dry Eye: A NanoString-Based Bioinformatic Analysis.
Invest Ophthalmol Vis Sci. 2025 Apr 1;66(4):80. doi: 10.1167/iovs.66.4.80.
本文引用的文献
1
SnapShot: Protein-protein interaction networks.
Cell. 2011 Mar 18;144(6):1000, 1000.e1. doi: 10.1016/j.cell.2011.02.025.
2
Literature curation of protein interactions: measuring agreement across major public databases.
Database (Oxford). 2010 Dec 22;2010:baq026. doi: 10.1093/database/baq026. Print 2010.
3
Network medicine: a network-based approach to human disease.
Nat Rev Genet. 2011 Jan;12(1):56-68. doi: 10.1038/nrg2918.
4
SnapShot: network motifs.
Cell. 2010 Oct 15;143(2):326-e1. doi: 10.1016/j.cell.2010.09.050.
5
High-quality binary interactome mapping.
Methods Enzymol. 2010;470:281-315. doi: 10.1016/S0076-6879(10)70012-4. Epub 2010 Mar 1.
6
Purification and characterization of HIV-human protein complexes.
Methods. 2011 Jan;53(1):13-9. doi: 10.1016/j.ymeth.2010.08.007. Epub 2010 Aug 12.
7
Mammalian microRNAs predominantly act to decrease target mRNA levels.
Nature. 2010 Aug 12;466(7308):835-40. doi: 10.1038/nature09267.
8
Quantifying E. coli proteome and transcriptome with single-molecule sensitivity in single cells.
Science. 2010 Jul 30;329(5991):533-8. doi: 10.1126/science.1188308.
9
Revisiting date and party hubs: novel approaches to role assignment in protein interaction networks.
PLoS Comput Biol. 2010 Jun 17;6(6):e1000817. doi: 10.1371/journal.pcbi.1000817.
10
Link communities reveal multiscale complexity in networks.
Nature. 2010 Aug 5;466(7307):761-4. doi: 10.1038/nature09182. Epub 2010 Jun 20.
Zotero 插件