Center for Cancer Systems Biology and Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Cell. 2011 Mar 18;144(6):986-98. doi: 10.1016/j.cell.2011.02.016.
Complex biological systems and cellular networks may underlie most genotype to phenotype relationships. Here, we review basic concepts in network biology, discussing different types of interactome networks and the insights that can come from analyzing them. We elaborate on why interactome networks are important to consider in biology, how they can be mapped and integrated with each other, what global properties are starting to emerge from interactome network models, and how these properties may relate to human disease.
复杂的生物系统和细胞网络可能是大多数基因型到表型关系的基础。在这里,我们回顾了网络生物学的基本概念,讨论了不同类型的互作网络以及分析它们可以获得的见解。我们详细阐述了互作网络在生物学中为什么很重要,它们如何相互映射和整合,从互作网络模型中开始出现哪些全局性质,以及这些性质如何与人类疾病相关。