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Crit Care. 2011;15(3):425. doi: 10.1186/cc10145. Epub 2011 May 17.

本文引用的文献

1
Effect of erythropoietin on level of circulating endothelial progenitor cells and outcome in patients after acute ischemic stroke.促红细胞生成素对急性缺血性脑卒中患者循环内皮祖细胞水平及预后的影响。
Crit Care. 2011;15(1):R40. doi: 10.1186/cc10002. Epub 2011 Jan 26.
2
Endothelial progenitor cells correlate with lesion volume and growth in acute stroke.内皮祖细胞与急性脑卒中的病灶体积和生长相关。
Neurology. 2010 Dec 7;75(23):2059-62. doi: 10.1212/WNL.0b013e318200d741.
3
Endothelial progenitor cell transplantation improves long-term stroke outcome in mice.内皮祖细胞移植可改善小鼠的长期脑卒中预后。
Ann Neurol. 2010 Apr;67(4):488-97. doi: 10.1002/ana.21919.
4
A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease.阿法达贝泊汀治疗2型糖尿病和慢性肾病的一项试验。
N Engl J Med. 2009 Nov 19;361(21):2019-32. doi: 10.1056/NEJMoa0907845. Epub 2009 Oct 30.
5
Recombinant human erythropoietin in the treatment of acute ischemic stroke.重组人促红细胞生成素治疗急性缺血性脑卒中。
Stroke. 2009 Dec;40(12):e647-56. doi: 10.1161/STROKEAHA.109.564872. Epub 2009 Oct 15.
6
The efficacy of erythropoietin and its analogues in animal stroke models: a meta-analysis.促红细胞生成素及其类似物在动物脑卒中模型中的疗效:一项荟萃分析。
Stroke. 2009 Sep;40(9):3113-20. doi: 10.1161/STROKEAHA.109.555789. Epub 2009 Jun 18.
7
Multifunctional actions of approved and candidate stroke drugs.已批准和候选中风药物的多功能作用。
Neurotherapeutics. 2009 Jan;6(1):43-52. doi: 10.1016/j.nurt.2008.10.032.
8
Level and value of circulating endothelial progenitor cells in patients after acute ischemic stroke.急性缺血性脑卒中患者循环内皮祖细胞的水平及价值
Stroke. 2008 Jan;39(1):69-74. doi: 10.1161/STROKEAHA.107.489401. Epub 2007 Dec 6.
9
The increase of circulating endothelial progenitor cells after acute ischemic stroke is associated with good outcome.急性缺血性中风后循环内皮祖细胞的增加与良好预后相关。
Stroke. 2007 Oct;38(10):2759-64. doi: 10.1161/STROKEAHA.107.484386. Epub 2007 Aug 30.
10
Administration of ex vivo-expanded bone marrow-derived endothelial progenitor cells attenuates focal cerebral ischemia-reperfusion injury in rats.给予经体外扩增的骨髓源性内皮祖细胞可减轻大鼠局灶性脑缺血再灌注损伤。
Neurosurgery. 2006 Sep;59(3):679-86; discussion 679-86. doi: 10.1227/01.NEU.0000229058.08706.88.

促红细胞生成素治疗脑卒中:是死是活?

Erythropoietin for stroke treatment: dead or alive?

机构信息

Department of Neurology, University Hospital Münster, Albert-Schweitzer-Straße 33, 48149 Münster, Germany.

出版信息

Crit Care. 2011;15(2):129. doi: 10.1186/cc10057. Epub 2011 Mar 9.

DOI:10.1186/cc10057
PMID:21418552
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3219325/
Abstract

Endothelial progenitor cell (EPC) mobilization from the bone marrow was considered to improve outcome after ischemic stroke. Erythropoietin (EPO) might be a potential candidate stroke drug that increases the number of circulating EPCs. In the previous issue of Critical Care, Yip and colleagues investigated the effect of EPO in stroke patients on both clinical outcome and EPC stimulation. Although beneficial effects of EPO were observed, several issues regarding EPO's suitability as a stroke drug remain.

摘要

内皮祖细胞(EPC)从骨髓动员被认为可以改善缺血性脑卒中的预后。促红细胞生成素(EPO)可能是一种增加循环 EPC 数量的潜在候选脑卒中药物。在《危重病医学》的前一期中,Yip 及其同事研究了 EPO 对脑卒中患者的临床结局和 EPC 刺激的影响。尽管观察到了 EPO 的有益作用,但 EPO 作为脑卒中药物的适用性仍存在一些问题。