Li Wei-Wei, Sun Xu-Guang
Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University; Beijing Ophthalmology & Visual Sciences Key Lab, Beijing 100005, China.
Zhonghua Yan Ke Za Zhi. 2011 Jan;47(1):79-82.
Conjunctiva epithelial stem cells are bipotent cells giving rise to both conjunctival epithelial cells and goblet cells. They play a central role in ocular surface homeostasis and wound repair, and also have great capacities of self-renewal, proliferation and differentiation. As a result, conjunctival epithelial stem cells are main resources of seed cells for tissue engineering conjunctiva. To review the current research of conjunctival epithelia stem cells such as their features, distribution, ways to identify stem cells, in vitro culture and induced differentiation to goblet cells.
结膜上皮干细胞是一种双能细胞，可分化产生结膜上皮细胞和杯状细胞。它们在眼表稳态和伤口修复中发挥着核心作用，并且具有很强的自我更新、增殖和分化能力。因此，结膜上皮干细胞是组织工程结膜种子细胞的主要来源。本文旨在综述结膜上皮干细胞的研究现状，包括其特征、分布、干细胞鉴定方法、体外培养以及向杯状细胞的诱导分化。
