Tuerxun Maimaiti, Hamulati Wupuer, Bai Lan, Peng Xiao-Mei, Dolikun Mamatyusupu
College of Life Sciences and Technology, Xinjiang University, Urumqi 830046, China.
Zhonghua Yi Xue Za Zhi. 2011 Jan 11;91(2):86-91.
To explore the association between polymorphism of cytochrome P450 1A1 Gene 3'-UTR (3'-untranslated region) 6235T-C and breast cancer with abnormal Hilit in Chinese Han population of Xinjiang.
The breast cancer patients were divided into four body fluids according to Uighur medical theories. And the technique of polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was employed to detect the genotypic and allelic frequencies of 6235T-C polymorphism situated in 3'-untranslated region of CYP1A1 gene in 137 breast cancer patients with abnormal Hilit and 148 normal control subjects in Han population of Xinjiang province.
(1) Significant differences in the genotypic and allelic distribution frequencies of CYP1A1 gene 3'-UTR6235T-C were found between breast cancer patients with abnormal Sapra Hilit and controls (χ(2) = 8.790, P = 0.012; χ(2) = 7.102, P = 0.008). The frequencies of CC genotype and C allele were significantly higher in breast cancer patients with abnormal Sapra Hilit (16.4% vs 39.8%) than in controls (4.7% vs 25.7%). (2) Significant differences in the genotypes and allelic distribution frequencies of CYP1A1 gene 3'-UTR6235T-C were found between breast cancer patients with abnormal Savda Hilit and controls (χ(2) = 6.638, P = 0.036; χ(2) = 5.824, P = 0.016). And the frequencies of TC, CC genotypes and C allele were significantly higher in breast cancer patients with abnormal Savda Hilit (56.9%, 9.8%, 39.2%) than those of the controls (41.9%, 4.7%, 25.7%).
The CC genotype and C allele of 6235T-C polymorphism of CYP1A1 may be linked with breast cancer with abnormal Sapra Hilit and abnormal savda Hilit in Chinese Han population of Xinjiang province. But they are not correlated with the susceptibility to breast cancer with abnormal Balgham Hilit.
探讨新疆汉族人群中细胞色素P450 1A1基因3'-非翻译区（3'-UTR）6235T-C多态性与异常体液型乳腺癌的相关性。
根据维吾尔医学理论，将乳腺癌患者分为四种体液类型。采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）技术，检测137例异常体液型乳腺癌患者及148例新疆汉族正常对照人群中CYP1A1基因3'-非翻译区6235T-C多态性的基因型及等位基因频率。
（1）异常黏液质型乳腺癌患者与对照组CYP1A1基因3'-UTR6235T-C基因型及等位基因分布频率存在显著差异（χ(2)=8.790，P = 0.012；χ(2)=7.102，P = 0.008）。异常黏液质型乳腺癌患者CC基因型和C等位基因频率（16.4%对39.8%）显著高于对照组（4.7%对25.7%）。（2）异常胆液质型乳腺癌患者与对照组CYP1A1基因3'-UTR6235T-C基因型及等位基因分布频率存在显著差异（χ(2)=6.638，P = 0.036；χ(2)=5.824，P = 0.016）。异常胆液质型乳腺癌患者TC、CC基因型及C等位基因频率（56.9%、9.8%、39.2%）显著高于对照组（41.9%、4.7%、25.7%）。
CYP1A1基因6235T-C多态性的CC基因型和C等位基因可能与新疆汉族人群异常黏液质型及异常胆液质型乳腺癌相关，但与异常黑胆质型乳腺癌易感性无关。
