醛糖还原酶 C-106T 基因多态性与日本 2 型糖尿病患者糖尿病视网膜病变有关。
Aldose reductase C-106T gene polymorphism is associated with diabetic retinopathy in Japanese patients with type 2 diabetes.
机构信息
Department of Metabolic Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.
出版信息
Diabetes Res Clin Pract. 2011 Jun;92(3):e57-60. doi: 10.1016/j.diabres.2011.02.017. Epub 2011 Mar 21.
Abstract
It is likely that the C allele of the polymorphism at position -106 in the promoter of aldose reductase gene, which codes a rate-limiting enzyme of the polyol pathway, is a susceptibility allele for diabetic retinopathy in Japanese type 2 diabetic patients.
摘要
这种多态性位于醛糖还原酶基因启动子的-106 位，该基因编码多元醇途径的限速酶，其 C 等位基因可能是日本 2 型糖尿病患者糖尿病视网膜病变的易感等位基因。
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