School of Psychology, University of Ottawa, 136 Jean-Jacques Lussier, Ottawa, Ontario, K1N 6N5, Canada.
Behav Brain Res. 2011 Sep 12;222(1):81-8. doi: 10.1016/j.bbr.2011.03.023. Epub 2011 Mar 21.
Several studies have documented an increased incidence of dementia among diabetic patients. In addition, impaired glucose regulation in both, younger and older adults, has been shown to be associated with neuropsychological deficits, particularly of episodic memory. The main purpose of this study was to examine this association in a large sample of young nondiabetic adults. All participants underwent a glucose tolerance test together with measures of insulin levels and lipids. Regression analyses revealed that glucoregulatory indices based on evoked glucose levels were significantly associated with the verbal memory performance of 122 young adults, independent of demographic and vascular risk factors. Participants were assessed after drinking glucose or saccharin, using a repeated-measures design. There was no effect of glucose on cognitive performance. Glucoregulatory indices calculated on the basis of insulin levels or fasting glucose levels explained less cognitive variability compared to indices based on evoked glucose levels. Cardiovascular risk factors were associated with hyperinsulinemia but these factors were not associated with cognitive performance in this young adult group. These findings suggest that cognitive decrements are observable in young, nondiabetic adults, prior to the onset of impaired glucose regulation and diabetes.
几项研究记录了糖尿病患者痴呆发病率的增加。此外，年轻人和老年人的葡萄糖调节受损都与神经心理缺陷有关，尤其是情景记忆。本研究的主要目的是在大量年轻非糖尿病成年人中检查这种关联。所有参与者都接受了葡萄糖耐量试验以及胰岛素水平和血脂测量。回归分析显示，基于诱发血糖水平的糖调节指数与 122 名年轻成年人的语言记忆表现显著相关，独立于人口统计学和血管危险因素。参与者在饮用葡萄糖或糖精后使用重复测量设计进行评估。葡萄糖对认知表现没有影响。基于胰岛素水平或空腹血糖水平计算的糖调节指数与基于诱发血糖水平的指数相比，解释的认知变异性较小。心血管危险因素与高胰岛素血症有关，但这些因素与该年轻人群的认知表现无关。这些发现表明，在葡萄糖调节受损和糖尿病发生之前，年轻的非糖尿病成年人就会出现认知能力下降。
