Department of Public Health and Clinical Medicine, Family Medicine, Umeå University, S-901 87 Umeå, Sweden.
Department of Community Medicine and Rehabilitation, Geriatric Medicine, Umeå University, S-901 85 Umeå, Sweden.
Diabetol Metab Syndr. 2015 Mar 15;7:20. doi: 10.1186/s13098-015-0014-7. eCollection 2015.
Elevated concentrations of plasma glucose appear to play a role in memory impairment, and it has been suggested that insulin might also have a negative effect on cognitive function. Our aim was to study whether glucose, insulin or insulin resistance are associated with episodic or semantic memory in a non-diabetic and non-demented population.
We linked and matched two population-based data sets identifying 291 participants (127 men and 164 women, mean age of 50.7 ± 8.0 years). Episodic and semantic memory functions were tested, and fasting plasma insulin, fasting plasma glucose, and 2-hour glucose were analysed along with other potential influencing factors on memory function. Since men and women display different results on memory functions they were analysed separately. Insulin resistance was calculated using the HOMA-IR method.
A higher fasting plasma glucose concentration was associated with lower episodic memory in women (r = -0.08, 95% CI -0.14; -0.01), but not in men. Plasma insulin levels and insulin resistance were not associated with episodic or semantic memory in women or in men after adjustments for age, fasting glucose, 2-hour glucose, BMI, education, smoking, cardiovascular disease, hypertension, cholesterol, and physical activity.
This indicates that fasting glucose but not insulin, might have impact on episodic memory in middle-aged women.
血浆葡萄糖浓度升高似乎与记忆障碍有关，有人认为胰岛素也可能对认知功能产生负面影响。我们的目的是研究在非糖尿病和非痴呆人群中，葡萄糖、胰岛素或胰岛素抵抗是否与情景记忆或语义记忆有关。
我们将两个基于人群的数据集进行了链接和匹配，确定了 291 名参与者（127 名男性和 164 名女性，平均年龄为 50.7±8.0 岁）。测试了情景记忆和语义记忆功能，并分析了空腹血浆胰岛素、空腹血糖和 2 小时血糖以及其他可能影响记忆功能的潜在因素。由于男性和女性在记忆功能上表现出不同的结果，因此分别进行了分析。使用 HOMA-IR 方法计算胰岛素抵抗。
较高的空腹血糖浓度与女性的情景记忆较差相关（r=-0.08，95%置信区间-0.14；-0.01），但与男性无关。在调整年龄、空腹血糖、2 小时血糖、BMI、教育、吸烟、心血管疾病、高血压、胆固醇和体力活动后，女性和男性的血浆胰岛素水平和胰岛素抵抗与情景记忆或语义记忆均无相关性。
这表明空腹血糖可能会影响中年女性的情景记忆，但胰岛素不会。
