Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney, Sydney, New South Wales, Australia.
Surv Ophthalmol. 2011 May-Jun;56(3):184-94. doi: 10.1016/j.survophthal.2010.08.007. Epub 2011 Mar 21.
Age-related macular degeneration (AMD) is the leading cause of blindness in people over 60 in western countries. Inflammatory markers have been implicated in the development and progression of AMD. C-reactive protein (CRP) is an inflammatory marker known to be associated with cardiovascular disease, and a link between AMD and CRP has been suggested. In this systematic review we summarize the currently available evidence from clinic-based and population-based studies investigating this association. A meta-analysis of evidence from eleven studies (41,690 study participants) shows that high serum levels (>3 mg/L) of CRP are associated with a two-fold likelihood of late onset AMD, compared to low levels (<1mg/L). Sub-group meta-analyses show a higher association in studies using ophthalmoscopic examination, compared to those using photographic grading (pooled odds ratio 3.83 vs 1.36), to determine AMD status, or in clinic-based samples compared to population-based studies.
年龄相关性黄斑变性（AMD）是西方国家 60 岁以上人群致盲的主要原因。炎症标志物与 AMD 的发生和进展有关。C 反应蛋白（CRP）是一种已知与心血管疾病相关的炎症标志物，并且已经有人提出 AMD 与 CRP 之间存在关联。在这项系统评价中，我们总结了目前基于临床和人群研究的证据，以调查这种关联。对 11 项研究（41690 名研究参与者）的证据进行的荟萃分析表明，与低水平（<1mg/L）相比，高水平（>3mg/L）的 CRP 血清水平与晚期 AMD 的发病风险增加两倍相关。亚组荟萃分析显示，在使用眼底镜检查确定 AMD 状态的研究中，与使用摄影分级（合并优势比 3.83 比 1.36）相比，或在基于临床的样本中与基于人群的研究相比，相关性更高。
