Yoon Byung Woo, Lee Young, Seo Je Hyun
Department of Internal Medicine, Chung-Ang University Gwangmyung Hospital, Gwangmyung 14353, Republic of Korea.
College of Medicine, Chung-Ang University, Seoul 06974, Republic of Korea.
Biomedicines. 2024 Apr 5;12(4):807. doi: 10.3390/biomedicines12040807.
Researchers have proposed a possible correlation between age-related macular degeneration (AMD) and inflammation or C-reactive protein (CRP) levels. We investigated the potential causal relationship between CRP levels and AMD. Single-nucleotide polymorphisms (SNPs) associated with CRP exposure were selected as the instrumental variables (IVs) with significance ( < 5 × 10) from the genome-wide association study (GWAS) meta-analysis data of Biobank Japan and the UK Biobank. GWAS data for AMD were obtained from 11 International AMD Genomics Consortium studies. An evaluation of causal estimates, utilizing the inverse-variance-weighted (IVW), weighted-median, MR-Egger, MR-Pleiotropy-Residual-Sum, and Outlier tests, was conducted in a two-sample Mendelian randomization (MR) study. We observed significant causal associations between CRP levels and AMD (odds ratio [OR] = 1.13, 95% CI = [1.02-1.24], and = 0.014 in IVW; OR = 1.18, 95% CI = [1.00-1.38], and = 0.044 in weight median; OR = 1.31, 95% CI = [1.13-1.52], and < 0.001 in MR-Egger). The causal relationship between CRP and AMD warrants further research to address the significance of inflammation as a risk factor for AMD.
研究人员提出了年龄相关性黄斑变性（AMD）与炎症或C反应蛋白（CRP）水平之间可能存在的关联。我们调查了CRP水平与AMD之间的潜在因果关系。从日本生物银行和英国生物银行的全基因组关联研究（GWAS）荟萃分析数据中，选择与CRP暴露相关的单核苷酸多态性（SNP）作为具有显著意义（<5×10）的工具变量（IV）。AMD的GWAS数据来自11项国际AMD基因组学联盟研究。在一项两样本孟德尔随机化（MR）研究中，利用逆方差加权（IVW）、加权中位数、MR-Egger、MR-多效性残差和离群值检验对因果估计进行了评估。我们观察到CRP水平与AMD之间存在显著的因果关联（IVW中优势比[OR]=1.13，95%可信区间=[1.02-1.24]，P=0.014；加权中位数中OR=1.18，95%可信区间=[1.00-1.38]，P=0.044；MR-Egger中OR=1.31，95%可信区间=[1.13-1.52]，P<0.001）。CRP与AMD之间的因果关系值得进一步研究，以探讨炎症作为AMD危险因素的重要性。
