睡眠后听觉诱发电位幅度下降反映了睡眠的稳态。
A postsleep decline in auditory evoked potential amplitude reflects sleep homeostasis.
机构信息
Department of Psychiatry, University of Wisconsin-Madison, Madison, WI 53719, USA.
出版信息
Clin Neurophysiol. 2011 Aug;122(8):1549-55. doi: 10.1016/j.clinph.2011.01.041. Epub 2011 Mar 21.
OBJECTIVE
It has been hypothesized that slow wave activity, a well established measure of sleep homeostasis that increases after waking and decreases after sleep, may reflect changes in cortical synaptic strength. If so, the amplitude of sensory evoked responses should also vary as a function of time awake and asleep in a way that reflects sleep homeostasis.
METHODS
Using 256-channel, high-density electroencephalography (EEG) in 12 subjects, auditory evoked potentials (AEP) and spontaneous waking data were collected during wakefulness before and after sleep.
RESULTS
The amplitudes of the N1 and P2 waves of the AEP were reduced after a night of sleep. In addition, the decline in N1 amplitude correlated with low-frequency EEG power during non-rapid eye movement sleep and spontaneous wakefulness, both homeostatically regulated measures of sleep need.
CONCLUSIONS
The decline in AEP amplitude after a night of sleep may reflect a homeostatic reduction in synaptic strength.
SIGNIFICANCE
These findings provide further evidence for a connection between synaptic plasticity and sleep homeostasis.
目的
有假说认为，慢波活动是睡眠内稳态的一个既定指标，在觉醒后增加，在睡眠后减少，可能反映了皮质突触强度的变化。如果是这样，感觉诱发电响应的幅度也应该随着清醒和睡眠的时间而变化，反映睡眠内稳态。
方法
在 12 名受试者中使用 256 通道高密度脑电图（EEG），在睡眠前和睡眠后清醒期间收集听觉诱发电位（AEP）和自发清醒数据。
结果
AEP 的 N1 和 P2 波的振幅在一夜睡眠后降低。此外，N1 振幅的下降与非快速眼动睡眠和自发清醒期间的低频 EEG 功率相关，这两个都是睡眠需求的内稳态调节指标。
结论
一夜睡眠后的 AEP 幅度下降可能反映了突触强度的内稳态降低。
意义
这些发现为突触可塑性和睡眠内稳态之间的联系提供了进一步的证据。
Zotero 插件